|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2003
Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma
1 First Dept of Internal Medicine and 2 Dept ofRadiology, Shinshu University School of Medicine, Matsumoto, Japan.
CORRESPONDENCE: K. Fujimoto, First Dept of Internal Medicine, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan. Fax: 81 263363722. E-mail: Keisaku@hsp.md.shinshu-u.ac.jp
Keywords: air trapping, airflow obstruction, airway remodelling, airway wall, bronchial asthma, high-resolution computed tomography
Received: September 15, 2002
Accepted July 22, 2003
The aim of this study was to examine the relationship between the structural changes in large and small airways in asymptomatic asthmatics quantified by high-resolution computed tomography (HRCT) and airflow obstruction.
The bronchial wall thickness at the trunk of the apical bronchus (B1) of the right upper lobe was used for assessment of the large airways. Air trapping, evaluated by the ratio of the average CT-determined values for the bilateral upper and lower lung segments at full expiration to that at full inspiration (E/I ratio), was used for assessment of the small airways. Measurements were obtained with a helical HRCT in 24 asymptomatic asthmatics followed by optimal treatment with inhaled and/or oral corticosteroids for >6 months. Prior (20–30 min) to the HRCT examination, all patients were given an inhaled bronchodilator.
The ratio of airway wall thickness to outer diameter (T/D) and the percentage wall area (WA%) at the B1 bronchus and the E/I ratio were significantly greater for the 14 asthmatics with deficient reversible airflow obstruction (forced expiratory volume in one second (FEV1) <80% prediced or FEV1/forced vital capacity <70% after bronchodilator inhalation) than for the 10 asthmatics with normal spirometry and seven normal subjects. T/D, WA%, and E/I ratio showed significant negative correlations with FEV1 % pred after bronchodilator inhalation. The E/I ratio also showed significant positive correlations with T/D, WA%, and residual volume/total lung capacity.
These findings suggest that, in spite of optimal treatment, structural changes in both large and small airways may simultaneously occur in asthmatics with deficient reversible airflow obstruction.
This article has been cited by other articles:
|
|
 |
|
  J. P. Williamson, A. L. James, M. J. Phillips, D. D. Sampson, D. R. Hillman, and P. R. Eastwood Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques Eur. Respir. J., July 1, 2009; 34(1): 42 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Aysola, E. A. Hoffman, D. Gierada, S. Wenzel, J. Cook-Granroth, J. Tarsi, J. Zheng, K. B. Schechtman, T. P. Ramkumar, R. Cochran, et al. Airway Remodeling Measured by Multidetector CT Is Increased in Severe Asthma and Correlates With Pathology Chest, December 1, 2008; 134(6): 1183 - 1191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Lee, T. Haselkorn, L. Borish, L. Rasouliyan, B. E. Chipps, and S. E. Wenzel Risk Factors Associated With Persistent Airflow Limitation in Severe or Difficult-to-Treat Asthma: Insights From the TENOR Study Chest, December 1, 2007; 132(6): 1882 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cohen, X. E, J. Tarsi, T. Ramkumar, T. K. Horiuchi, R. Cochran, S. DeMartino, K. B. Schechtman, I. Hussain, M. J. Holtzman, et al. Epithelial Cell Proliferation Contributes to Airway Remodeling in Severe Asthma Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 138 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. de Lange, T. A. Altes, J. T. Patrie, J. D. Gaare, J. J. Knake, J. P. Mugler III, and T. A. Platts-Mills Evaluation of Asthma With Hyperpolarized Helium-3 MRI: Correlation With Clinical Severity and Spirometry. Chest, October 1, 2006; 130(4): 1055 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. de Jong, N. L. Muller, P. D. Pare, and H. O. Coxson Computed tomographic imaging of the airways: relationship to structure and function Eur. Respir. J., July 1, 2005; 26(1): 140 - 152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Guerra Clinical remission of asthma: what lies beyond? Thorax, January 1, 2005; 60(1): 5 - 6. [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Lee, J.-S. Park, J.-H. Hwang, S.-W. Park, S.-t. Uh, Y.-H. Kim, and C.-S. Park High-Resolution CT Findings in Patients With Near-Fatal Asthma: Comparison of Patients With Mild-to-Severe Asthma and Normal Control Subjects and Changes in Airway Abnormalities Following Steroid Treatment Chest, December 1, 2004; 126(6): 1840 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mauad, L. F. F. Silva, M. A. Santos, L. Grinberg, F. D. C. Bernardi, M. A. Martins, P. H. N. Saldiva, and M. Dolhnikoff Abnormal Alveolar Attachments with Decreased Elastic Fiber Content in Distal Lung in Fatal Asthma Am. J. Respir. Crit. Care Med., October 15, 2004; 170(8): 857 - 862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.T. Holgate Lessons learnt from the epidemic of asthma QJM, May 1, 2004; 97(5): 247 - 257. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |