HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Krane, M. Articles by Griese, M. Search for Related Content PubMed PubMed Citation Articles by Krane, M. Articles by Griese, M.

Surfactant protein D in serum from patients with allergic bronchopulmonary aspergillosis

Children's Hospital, Ludwig Maximilians University of Munich, Munich, Germany

CORRESPONDENCE: M. Griese, Children's Hospital, Dr. von Hauner Kinderspital, Lindwurmstr. 4, D-80337, München, Germany. Fax: 49 8951607872. E-mail: mgriese@helios.med.uni-muenchen.de

Keywords: allergic bronchopulmonary aspergillosis, cystic fibrosis, surfactant protein D

Received: May 30, 2003
Accepted June 22, 2003

Surfactant protein D (SP-D) interacts with Aspergillus fumigatus and is strongly increased in the lavage from animals with acute allergic reactions to the fungus, suggesting a central role for SP-D. As the course of cystic fibrosis (CF) is often complicated by an allergic bronchopulmonary aspergillosis (ABPA), the authors hypothesised that SP-D may also be increased in serum during an ABPA, potentially assisting in its diagnosis and follow-up.

In 22 patients with CF (11 with ABPA, 11 matched without ABPA) and 19 control patients without a pulmonary disease, SP-D concentrations in serum were assessed by an enzyme immunoassay.

Serum SP-D in CF patients (130±16 ng·mL^–1 (mean±sem)) was significantly higher than in the controls without lung disease (66±8 ng·mL^–1). During the whole ABPA-episode, SP-D level did not change significantly, despite large changes of total serum immunoglobulin E. There was a clear negative correlation between SP-D concentration and overall lung function, i.e. forced expiratory volume in one second and forced vital capacity.

Serum level of surfactant protein D may be of value to follow pulmonary function and lung injury in cystic fibrosis patients. Surfactant protein D serum levels are not helpful for the diagnosis and follow-up of an allergic bronchopulmonary aspergillosis episode, contrary to what was expected from animal experiments.

This article has been cited by other articles:

				D. A. Lomas, E. K. Silverman, L. D. Edwards, N. W. Locantore, B. E. Miller, D. H. Horstman, R. Tal-Singer, and on behalf of the Evaluation of COPD Longitudinally Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD Eur. Respir. J., July 1, 2009; 34(1): 95 - 102. [Abstract] [Full Text] [PDF]

				D. D. Sin, S. F. P. Man, D. D. Marciniuk, G. Ford, M. FitzGerald, E. Wong, E. York, R. R. Mainra, W. Ramesh, L. S. Melenka, et al. The Effects of Fluticasone with or without Salmeterol on Systemic Biomarkers of Inflammation in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., June 1, 2008; 177(11): 1207 - 1214. [Abstract] [Full Text] [PDF]

				D. D. Sin, P. S. Pahlavan, and S.F. P. Man Review: Surfactant protein D: A lung specific biomarker in COPD? Therapeutic Advances in Respiratory Disease, April 1, 2008; 2(2): 65 - 74. [Abstract] [PDF]

				P. Latzin, D. Hartl, N. Regamey, U. Frey, M. H. Schoeni, and C. Casaulta Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis Eur. Respir. J., January 1, 2008; 31(1): 36 - 42. [Abstract] [Full Text] [PDF]

				D. Hartl, P. Latzin, G. Zissel, M. Krane, S. Krauss-Etschmann, and M. Griese Chemokines Indicate Allergic Bronchopulmonary Aspergillosis in Patients with Cystic Fibrosis Am. J. Respir. Crit. Care Med., June 15, 2006; 173(12): 1370 - 1376. [Abstract] [Full Text] [PDF]

				G. L. Sorensen, J. Madsen, K. Kejling, I. Tornoe, O. Nielsen, P. Townsend, F. Poulain, C. H. Nielsen, K. B. M. Reid, S. Hawgood, et al. Surfactant protein D is proatherogenic in mice Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2286 - H2294. [Abstract] [Full Text] [PDF]

				G. L. Sorensen, J. v. B. Hjelmborg, K. O. Kyvik, M. Fenger, A. Hoj, C. Bendixen, T. I. A. Sorensen, and U. Holmskov Genetic and environmental influences of surfactant protein D serum levels Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L1010 - L1017. [Abstract] [Full Text] [PDF]

				Q. A. Al-Salmi, J. N. Walter, G. N. Colasurdo, M. M. Sockrider, E. O. Smith, H. Takahashi, and L. L. Fan Serum KL-6 and Surfactant Proteins A and D in Pediatric Interstitial Lung Disease Chest, January 1, 2005; 127(1): 403 - 407. [Abstract] [Full Text] [PDF]