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Lymphoepithelioma-like carcinoma of the lung in a patient withsilicosis

University Depts of ¹ Medicine, ² Diagnostic Radiology and ³ Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China

CORRESPONDENCE: K.W.T. Tsang, Division of Respiratory and Critical Care Medicine, UniversityDept of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China. Fax: 852 29049443. E-mail: kwttsang@hkucc.hku.hk

Keywords: chemotherapy, lymphoepithelioma, silicosis

Received: December 11, 2002
Accepted February 17, 2003

Abstract

Silicosis is an important form of pneumoconiosis, which is caused by significant exposure to crystalline silica. The carcinogenicity of silica, despite traditional beliefs, in relation to lung cancer has been controversial. Lymphoepithelioma-like carcinoma of the lung, an Epstein-Barr virus-associated undifferentiated carcinoma, is a rare entity of pulmonary malignancy, which tends to affect young nonsmoking Asians.

The first case of silicosis, initially complicated by pulmonary tuberculosis, which later developed into advanced lymphoepithelioma-like carcinoma of the lung is reported. A combination of 5-fluorouracil, cisplatin and calcium folinate resulted in partial tumour response.

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