ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by de Jong, P.A.
Right arrow Articles by Coxson, H.O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Jong, P.A.
Right arrow Articles by Coxson, H.O.
Eur Respir J 2003; 22:235-238
Copyright ©ERS Journals Ltd 2003


Estimation of lung growth using computed tomography

P.A. de Jong1, Y. Nakano3, M.H. Lequin2, P.J. Merkus1, H.A. Tiddens1, J.C. Hogg3 and H.O. Coxson4

1 Dept of Paediatric Pulmonology and 2 Dept of Paediatric Radiology, Sophia Children's Hospital, Erasmus Medical Centre Rotterdam, Rotterdam, the Netherlands. 3 University of British Columbia, McDonald Research Laboratory and iCAPTURE Centre, St Paul's Hospital and 4 Dept of Radiology, Vancouver Hospital and Health Science Centre, Vancouver, BC, Canada

CORRESPONDENCE: H.O. Coxson, Vancouver Hospital and Health Science Centre, Dept of Radiology, 855 West 12th Avenue, Vancouver, BC Canada, V5Z 1M9. Fax: 1 6048754319. E-mail: hcoxson@vanhosp.bc.ca

Keywords: computed tomography, lung development, normal lung, quantitative computed tomography analysis

Received: September 30, 2002
Accepted February 26, 2003

P.A. de Jong was supported by a fellowship from the "Gerrit Jan Mulder Stichting", Erasmus University, Erasmus Medical Centre Rotterdam, Rotterdam, the Netherlands. H. Coxson is a Parker B. Francis Fellow in Pulmonary Research.

Anatomical studies suggest that normal lungs grow by rapid alveolar addition until about 2 yrs of age followed by a gradual increase in alveolar dimensions.

The aim of this study was to examine the hypothesis that normal lung growth can be monitored by computed tomography (CT). Therefore, the gas volume per gram of lung tissue was estimated from measurements of lung density obtained from CT scans performed on children throughout the growth period.

CT scans were performed on 17 males and 18 females, ranging in age from 15 days–17.6 yrs. CT-measured lung weight was correlated with predicted post mortem values and CT measured gas volume with predicted values of functional residual capacity. The median value for lung expansion was 1.86 mL·g–1 at 15 days, decreased to 0.79 mL·g–1 by 2 yrs and then increased steadily to 5.07 mL·g–1 at 17 yrs.

Computed tomography scans can be used to estimate lung weight, gas volume and expansion of normal lungs during the growth period. The increase in the lung expansion after the age of 2 yrs suggests progressive alveolar expansion with increasing lung volume.




This article has been cited by other articles:


Home page
J. Appl. Physiol.Home page
P. Ravikumar, C. Yilmaz, D. M. Dane, R. L. Johnson Jr., A. S. Estrera, C. C. W. Hsia, and (With the Technical Assistance of Richard T. Hogg
Developmental signals do not further accentuate nonuniform postpneumonectomy compensatory lung growth
J Appl Physiol, March 1, 2007; 102(3): 1170 - 1177.
[Abstract] [Full Text] [PDF]


Home page
ERRHome page
C. C. W. Hsia
Quantitative morphology of compensatory lung growth
Eur. Respir. Rev., December 1, 2006; 15(101): 148 - 156.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
P. A. de Jong, F. R. Long, J. C. Wong, P. J. Merkus, H. A. Tiddens, J. C. Hogg, and H. O. Coxson
Computed tomographic estimation of lung dimensions throughout the growth period
Eur. Respir. J., February 1, 2006; 27(2): 261 - 267.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
P. A. de Jong, Y. Nakano, W. C. Hop, F. R. Long, H. O. Coxson, P. D. Pare, and H. A. Tiddens
Changes in Airway Dimensions on Computed Tomography Scans of Children with Cystic Fibrosis
Am. J. Respir. Crit. Care Med., July 15, 2005; 172(2): 218 - 224.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
P. A. de Jong, N. L. Muller, P. D. Pare, and H. O. Coxson
Computed tomographic imaging of the airways: relationship to structure and function
Eur. Respir. J., July 1, 2005; 26(1): 140 - 152.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
H. O. Coxson, I. H. T. Chan, J. R. Mayo, J. Hlynsky, Y. Nakano, and C. L. Birmingham
Early Emphysema in Patients with Anorexia Nervosa
Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 748 - 752.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
A.A. Hislop
Lung growth and computed tomography
Eur. Respir. J., August 1, 2003; 22(2): 195 - 196.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the European Respiratory Society.