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1 Dept of Anaesthesiology and Critical Care Medicine and 2 Dept of Environmental Health Sciences/Division of Physiology, The Johns Hopkins University, Baltimore, MD, USA
CORRESPONDENCE: R.H. Brown, Physiology, Room 7006, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA. Fax: 1 4109550299. E-mail: rbrown2@jhem.jhmi.edu
Keywords: airways, asthma, bronchoconstriction, bronchodilation, high-resolution computed tomography
Received: October 2, 2002
Accepted February 25, 2003
This study was supported by National Institutes of Health Grant PO1 HL10342 and ES-03819 .
Deep inspirations (DI) have been shown to have both bronchoprotective and bronchodilator effects in healthy subjects. The bronchodilator effects of a DI appear to be impaired in asthmatics compared with healthy subjects. This study investigated the role of nitric oxide (NO) in the bronchodilator role of a DI.
In five anaesthetised and ventilated dogs, high-resolution computed tomography was used to measure the changes in airway size after a small (25 cmH2O) and large (45 cmH2O) DI before and after administering NG-nitro-l-arginine methyl ester to block NO synthesis.
The depth of the inspiratory manoeuvre during a deep inspiration determined the subsequent qualitative behaviour of the airway response. Inflation to relatively high pressure resulted in airway dilation, whereas one to lower pressure leads to airway constriction. When NG-nitro-L-arginine methyl ester was administered, both a large and a small deep inspiration resulted in subsequent airway constriction. These results support the idea that nitric oxide may be a potential bronchoprotective agent in the airways.
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