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Sleep-disordered breathing and hormones

¹ Dept of Pulmonary Diseases, Turku University Central Hospital and ² Sleep Research Unit, Dept of Physiology, University of Turku, Turku, Finland

CORRESPONDENCE: T. Saaresranta, University of Turku, Sleep Research Unit, Lemminkäisenkatu 2, 20520 Turku, Finland. Fax: 358 23337520. E-mail: tarja.saaresranta@tyks.fi

Keywords: cardiovascular diseases, continuous positive airway pressure, hormones, sleep apnoea, treatment

Received: July 10, 2002
Accepted February 25, 2003

This study was supported by the Finnish Anti-Tuberculosis Association Foundation, Emil Aaltonen Foundation and Paulo Foundation.

Abstract

Sleep-disordered breathing (SDB) is not only a problem of the upper airway but is a systemic condition with endocrine and metabolic interactions. The accumulating body of evidence shows that SDB induces changes in the serum levels or secretory patterns of several hormones. Conversely, various endocrine disorders and hormone therapies may induce, exacerbate or alleviate SDB.

Much of the understanding of the interactions between hormones and sleep-disordered breathing derive from intervention studies with nasal continuous positive airway pressure therapy. Better understanding of hormones and breathing may open new perspectives in developing strategies to prevent, alleviate or cure sleep-disordered breathing and its systemic consequences.

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