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Copyright ©ERS Journals Ltd 2003
Increased tumour necrosis factor-
plasma levels during moderate-intensity exercise in COPD patients
1 Servei de Pneumologia (ICPCT), 4 Servicio de Bioquímica Clínica (Unitat d' Estudi del Càncer), and 5 Liver Unit (Institute of Digestive Diseases) and Higher Scientific Research Council, Hospital Clinic, Faculty of Medicine, August Pi i Sunyer Biomedical Research Institute, and 2 Dept of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain. 5 Faculty of Physical Education and Physiotherapy, Catholic University of Louvain, Louvain, Belgium
CORRESPONDENCE: J. Roca, Servei de Pneumologia, Hospital Clínic, Villarroel 170, Barcelona, 08036, Spain. Fax: 34 932275455. E-mail: jroca@clinic.ub.es
Keywords: chronic obstructive pulmonary disease, cytokines, exercise training, muscle redox capacity, skeletal muscle
Received: May 22, 2002
Accepted December 20, 2002
This study was supported by grants FIS 99/0029 and 00/0281 from the Spanish Fund for Health Research, e-Remedy (IST-2000-25146) from the European Union (FP5) and Comissionat per a Universitats i Recerca de la Generalitat de Catalunya (1999 SGR 00228). R.A. Rabinovich and T. Troosters were research fellows supported by the European Respiratory Society (2000). M. Figueras is the recipient of a predoctoral scholarship from the Ministry of Education and Culture of the Spanish Government. Support was also received from E. Jaeger GmbH, Würzburg, Germany.
Post-training downregulation of muscle tumour necrosis factor (TNF)-
Eleven COPD patients (forced expiratory volume in one second 40±4.4% of the predicted value) and six age-matched controls were studied. Pre- and post-training levels of TNF-
Moderate-intensity constant-work-rate exercise (11 min at 40% of pretraining peak work-rate) increased pretraining plasma TNF-
It is concluded that moderate-intensity exercise abnormally increases plasma tumour necrosis factor-
messenger ribonucleic acid (mRNA) expression and decrease in cellular TNF- levels have been reported in the elderly. It is hypothesised that chronic obstructive pulmonary disease (COPD) patients may not show these adaptations due to their reduced ability to increase muscle antioxidant capacity with training. , soluble TNF receptors (sTNFRs: sTNFR55 and sTNFR75) and interleukin (IL)-6 in plasma at rest and during exercise and vastus lateralis TNF- mRNA were examined. levels in COPD patients (from 17±3.2 to 23±2.7 pg·mL–1; p<0.005) but not in controls (from 19±4.6 to 19±3.2 pg·mL–1). No changes were observed in sTNFRs or IL-6 levels. After 8 weeks' endurance training, moderate-intensity exercise increased plasma TNF- levels similarly to pretraining (from 16±3 to 21±4 pg·mL–1; p<0.01). Pretraining muscle TNF- mRNA expression was significantly higher in COPD patients than in controls (29.3±13.9 versus 5.0±1.5 TNF-/18S ribonucleic acid, respectively), but no changes were observed after exercise or training. levels in chronic obstructive pulmonary disease patients without exercise-induced upregulation of the tumour necrosis factor- gene in skeletal muscle.
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