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Rigid bronchoscopy induces bacterial translocation: an experimental study in rats

Depts of ¹ Paediatric Surgery, ² Chest Diseases, ³ Otorhinolaryngology, and ⁴ Clinical Microbiology and Infection Diseases, Mersin University School of Medicine, Mersin, Turkey

CORRESPONDENCE: A. Nayci, Mercin University School of Medicine, Dept of Paediatric Surgery, Mersin, Turkey. Fax: 90 3243288742. E-mail: anayci@mersin.edu.tr

Keywords: bacteraemia, bacterial translocation, bronchoscopy

Received: July 29, 2002
Accepted December 12, 2002

Bronchoscopy has the potential to propagate infections. Bacterial translocation was hypothesised to be the cause of infections observed following bronchoscopy and this study was designed to assess the risk of bacterial translocation following rigid bronchoscopy in rats.

A total of 30 rats were evaluated. The study group (n=15) underwent rigid bronchoscopy. Arterial blood gas analysis was performed in all rats. Blood and tissue cultures from the ileum, caecum, mesenteric lymph nodes, liver, spleen, mediastinal lymph nodes and lung were obtained 24 h following bronchoscopy.

Bacterial translocation to the mesenteric lymph nodes was found in seven of 15 rats (46.7%) that underwent bronchoscopy, compared with none of the controls. Of the seven positives, three rats (42.8%) also demonstrated other organ involvement, such as the liver and spleen. Escherichia coli, Salmonella typhymirium, S. enteritidis and Pseudomonas spp. were found as translocating bacteria. In the study group, pH and arterial oxygen tension were significantly lower and arterial carbon dioxide tension was higher, compared with controls.

This study shows that rigid bronchoscopy may induce bacterial translocation in rats. Further investigations aimed at understanding the clinical consequences of this phenomenon are warranted.

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