HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (13) Citing Articles via Google Scholar Google Scholar Articles by Jones, H.A. Articles by Morrell, N.W. Search for Related Content PubMed PubMed Citation Articles by Jones, H.A. Articles by Morrell, N.W.

In vivo assessment of lung inflammatory cell activity in patients with COPD and asthma

Division of Medicine and National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK

CORRESPONDENCE: H.A. Jones, Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, W12 0NN, UK. E-mail: hazel.jones@ic.ac.uk. Fax: 44 2087439733

Keywords: ¹⁸F-fluorodeoxyglucose, neutrophils, macrophages, PK11195, positron emission tomography

Received: June 6, 2002
Accepted October 21, 2002

This study was funded by a Research Donation from GlaxoSmithKline, UK.

Abstract

The involvement of inflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD) and asthma is well established. This study aimed to quantify differences in inflammatory cell function in situ in these patients as compared to normal subjects.

Positron emission tomography was used to assess neutrophil activity (¹⁸F-fluorodeoxyglucose (¹⁸FDG)) and macrophage accumulation (¹¹C-PK11195) in six patients with COPD, six chronic asthmatics and five age-matched normal control subjects.

¹⁸FDG uptake was greater in COPD than in normal subjects, with no increase in asthmatics. The mean slope of ¹⁸FDG uptake, corrected for volume of distribution, was 4.0 min^–1 in COPD patients compared with 1.5 min^–1 in control subjects and 1.7 min^–1 in asthmatics. Mean ¹¹C-PK11195 uptake (plateau tissue:plasma) was higher in four of six COPD patients (10.8) and three of five asthmatics (11.8) than the maximum value in control subjects (6.2).

From this preliminary study the authors conclude that positron emission tomography may be useful to assess polymorphonuclear neutrophil and macrophage activity in vivo in chronic obstructive pulmonary disease and asthma, and may reveal differences in cell behaviour between the study groups. In addition, positron emission tomography may provide indices of disease activity for future therapeutic studies.

This article has been cited by other articles:

				M. B. Dolovich and D. P. Schuster Positron Emission Tomography and Computed Tomography versus Positron Emission Tomography Computed Tomography: Tools for Imaging the Lung Proceedings of the ATS, August 1, 2007; 4(4): 328 - 333. [Abstract] [Full Text] [PDF]

				D. P. Schuster The Opportunities and Challenges of Developing Imaging Biomarkers to Study Lung Function and Disease Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 224 - 230. [Abstract] [Full Text] [PDF]

				D. P. Schuster, S. L. Brody, Z. Zhou, M. Bernstein, R. Arch, D. Link, and M. Mueckler Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L845 - L851. [Abstract] [Full Text] [PDF]

				D. L. Chen, D. B. Rosenbluth, M. A. Mintun, and D. P. Schuster FDG-PET imaging of pulmonary inflammation in healthy volunteers after airway instillation of endotoxin J Appl Physiol, May 1, 2006; 100(5): 1602 - 1609. [Abstract] [Full Text] [PDF]

				P. W. Jones and A. G. N. Agusti Outcomes and markers in the assessment of chronic obstructive pulmonary disease. Eur. Respir. J., April 1, 2006; 27(4): 822 - 832. [Abstract] [Full Text] [PDF]

				H. A. Jones Inflammation Imaging Proceedings of the ATS, December 1, 2005; 2(6): 545 - 548. [Abstract] [Full Text] [PDF]

				P. W. Ind COPD disease progression and airway inflammation: uncoupled by smoking cessation Eur. Respir. J., November 1, 2005; 26(5): 764 - 766. [Full Text] [PDF]

				M. Dolovich and R. Labiris Imaging Drug Delivery and Drug Responses in the Lung Proceedings of the ATS, December 1, 2004; 1(4): 329 - 337. [Abstract] [Full Text] [PDF]

				D. L. Chen, M. A. Mintun, and D. P. Schuster Comparison of Methods to Quantitate 18F-FDG Uptake with PET During Experimental Acute Lung Injury J. Nucl. Med., September 1, 2004; 45(9): 1583 - 1590. [Abstract] [Full Text] [PDF]