| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Dept of Thoracic Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Royal Brompton and Harefield NHS Trust, London, UK
CORRESPONDENCE: S.A. Kharitonov, Dept of Thoracic Medicine, National Heart & Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK. Fax: 0207 3518126. E-mail: s.kharitonov@imperial.ac.uk
Keywords: asthma, exhaled nitric oxide, fractional exhaled nitric oxide measurements
Received: July 24, 2002
Accepted November 12, 2002
This study was supported by Aerocrine AB, Stockholm, Sweden.
Airway inflammation in asthma is not measured routinely in clinical practice. Fractional exhaled nitric oxide (FENO), a marker of airway inflammation, is increasingly used as an outcome measure in asthma intervention studies and yet the reproducibility of FENO measurements is unknown.
The reproducibility, daytoday, diurnal variation and perception of standardised FENO measurements were examined in 59 subjects (40 children aged 7–13 yrs and 19 adults aged 18–60 yrs), both healthy (n=30) and with mild (n=29) asthma. FENO was measured on five consecutive days (four measurements on the same day) for adults and twice on the same day for children.
The coefficient of reproducibility expressed as the mean pooled standard deviation (n=59, 675 estimations) was 2.11 parts per billion (ppb) and intraclass correlation coefficient was 0.99 in both children and adults. FENO was significantly higher in asthma subjects (32.3 ppb) than in healthy subjects (16.3 ppb). There was no diurnal or daytoday variation, or a learning effect, as the result of FENO measurements were identical at results of the beginning and at the end of the study.
It was concluded that fractional exhaled nitric oxide measurements are simple, reproducible, free from diurnal and daytoday variation, and acceptable by both healthy and asthmatic adults and children, as a part of their routine visit to a physician.
This article has been cited by other articles:
|
|
 |
|
  K. G. Lim and C. Mottram The Use of Fraction of Exhaled Nitric Oxide in Pulmonary Practice Chest, May 1, 2008; 133(5): 1232 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al. Outcomes for COPD pharmacological trials: from lung function to biomarkers Eur. Respir. J., February 1, 2008; 31(2): 416 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kovesi, R. Kulka, and R. Dales Exhaled Nitric Oxide Concentration Is Affected by Age, Height, and Race in Healthy 9- to 12-Year-Old Children Chest, January 1, 2008; 133(1): 169 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Balbi, P. Pignatti, M. Corradi, P. Baiardi, L. Bianchi, G. Brunetti, A. Radaeli, G. Moscato, A. Mutti, A. Spanevello, et al. Bronchoalveolar lavage, sputum and exhaled clinically relevant inflammatory markers: values in healthy adults Eur. Respir. J., October 1, 2007; 30(4): 769 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Travers, S. Marsh, S. Aldington, M. Williams, P. Shirtcliffe, A. Pritchard, M. Weatherall, and R. Beasley Reference Ranges for Exhaled Nitric Oxide Derived from a Random Community Survey of Adults Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 238 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Shaw, M. A. Berry, M. Thomas, R. H. Green, C. E. Brightling, A. J. Wardlaw, and I. D. Pavord The Use of Exhaled Nitric Oxide to Guide Asthma Management: A Randomized Controlled Trial Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 231 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brindicci, K. Ito, P. J. Barnes, and S. A. Kharitonov Differential Flow Analysis of Exhaled Nitric Oxide in Patients With Asthma of Differing Severity Chest, May 1, 2007; 131(5): 1353 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kharitonov and P. J. Barnes Exhaled biomarkers. Chest, November 1, 2006; 130(5): 1541 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Haahtela, K. Tamminen, L. P. Malmberg, O. Zetterstrom, J. Karjalainen, H. Yla-Outinen, T. Svahn, T. Ekstrom, and O. Selroos Formoterol as needed with or without budesonide in patients with intermittent asthma and raised NO levels in exhaled air: a SOMA study Eur. Respir. J., October 1, 2006; 28(4): 748 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D R Taylor, M W Pijnenburg, A D Smith, and J C D Jongste Exhaled nitric oxide measurements: clinical application and interpretation. Thorax, September 1, 2006; 61(9): 817 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Barnes, B. Chowdhury, S. A. Kharitonov, H. Magnussen, C. P. Page, D. Postma, and M. Saetta Pulmonary Biomarkers in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., July 1, 2006; 174(1): 6 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Gelb, C. Flynn Taylor, C. M. Shinar, C. Gutierrez, and N. Zamel Role of Spirometry and Exhaled Nitric Oxide To Predict Exacerbations in Treated Asthmatics Chest, June 1, 2006; 129(6): 1492 - 1499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ihre, P. Gyllfors, L. E. Gustafsson, M. Kumlin, and B. Dahlen Early rise in exhaled nitric oxide and mast cell activation in repeated low-dose allergen challenge Eur. Respir. J., June 1, 2006; 27(6): 1152 - 1159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Choi, L. A. Hoffman, G. W. Rodway, and J. M. Sethi Markers of lung disease in exhaled breath: nitric oxide. Biol Res Nurs, April 1, 2006; 7(4): 241 - 255. [Abstract] [PDF]
|
|
|
|
|
|
P.-O. Ehrs, B.-M. Sundblad, and K. Larsson Quality of Life and Inflammatory Markers in Mild Asthma Chest, March 1, 2006; 129(3): 624 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 ATS Workshop Proceedings: Exhaled Nitric Oxide and Nitric Oxide Oxidative Metabolism in Exhaled Breath Condensate. Proceedings of the ATS, January 1, 2006; 3(2): 131 - 145. [Full Text] [PDF]
|
|
|
|
|
|
F. Buchvald, M. N. Hermansen, K. G. Nielsen, and H. Bisgaard Exhaled Nitric Oxide Predicts Exercise-Induced Bronchoconstriction in Asthmatic School Children Chest, October 1, 2005; 128(4): 1964 - 1967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Vints, E. Oostveen, G. Eeckhaut, M. Smolders, and W. A. De Backer Time-Dependent Effect of Nitrate-Rich Meals on Exhaled Nitric Oxide in Healthy Subjects Chest, October 1, 2005; 128(4): 2465 - 2470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Smith, J. O. Cowan, K. P. Brassett, S. Filsell, C. McLachlan, G. Monti-Sheehan, G. P. Herbison, and D. R. Taylor Exhaled Nitric Oxide: A Predictor of Steroid Response Am. J. Respir. Crit. Care Med., August 15, 2005; 172(4): 453 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brindicci, K. Ito, O. Resta, N. B. Pride, P. J. Barnes, and S. A. Kharitonov Exhaled nitric oxide from lung periphery is increased in COPD Eur. Respir. J., July 1, 2005; 26(1): 52 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Smith, J. O. Cowan, K. P. Brassett, G. P. Herbison, and D. R. Taylor Use of Exhaled Nitric Oxide Measurements to Guide Treatment in Chronic Asthma N. Engl. J. Med., May 26, 2005; 352(21): 2163 - 2173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005 Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 912 - 930. [Full Text] [PDF]
|
|
|
|
|
|
L. M. Fabbri Does Mild Persistent Asthma Require Regular Treatment? N. Engl. J. Med., April 14, 2005; 352(15): 1589 - 1591. [Full Text] [PDF]
|
|
|
|
|
|
M W Pijnenburg, W Hofhuis, W C Hop, and J C De Jongste Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission Thorax, March 1, 2005; 60(3): 215 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Baur and L. Barbinova Latex allergen exposure increases exhaled nitric oxide in symptomatic healthcare workers Eur. Respir. J., February 1, 2005; 25(2): 309 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kharitonov and P. J. Barnes Effects of Corticosteroids on Noninvasive Biomarkers of Inflammation in Asthma and Chronic Obstructive Pulmonary Disease Proceedings of the ATS, November 1, 2004; 1(3): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Gelb, C. F. Taylor, E. Nussbaum, C. Gutierrez, A. Schein, C. M. Shinar, M. J. Schein, J. D. Epstein, and N. Zamel Alveolar and Airway Sites of Nitric Oxide Inflammation in Treated Asthma Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 737 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Taylor, A. D. Smith, J. O. Cowan, G. P. Herbison, and D. R. Taylor Effect of Caffeine Ingestion on Exhaled Nitric Oxide Measurements in Patients with Asthma Am. J. Respir. Crit. Care Med., May 1, 2004; 169(9): 1019 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A M Li, C Lex, A Zacharasiewicz, E Wong, E Erin, T Hansel, N M Wilson, and A Bush Cough frequency in children with stable asthma: correlation with lung function, exhaled nitric oxide, and sputum eosinophil count Thorax, November 1, 2003; 58(11): 974 - 978. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
