ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paris, C.
Right arrow Articles by Thiberville, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paris, C.
Right arrow Articles by Thiberville, L.
Eur Respir J 2003; 21:332-341
Copyright ©ERS Journals Ltd 2003


Occupational and nonoccupational factors associated with high grade bronchial pre-invasive lesions

C. Paris1, J. Benichou2, S. Bota3, S. Sagnier1, J. Metayer4, S. Eloy1, J-B. Auliac3, G. Nouvet3 and L. Thiberville3

Depts of 1 Occupational Diseases, 2 Biostatistics, 3 Pneumology, and the4 Pathology Laboratory, Rouen University Hospital

CORRESPONDENCE: C. Paris, Occupational Diseases Dept, Rouen University Hospital, 1 rue de Germont, 76031, Rouen Cedex, France. Fax: 33 232888184. E-mail: christophe.paris@chu-rouen.fr

Keywords: asbestos, bronchoscopy, lung neoplasms, occupational exposure

Received: January 1, 2002
Accepted September 30, 2002

This research was supported by a "Programme Hospitalier de Recherche Clinique" grant from the French Ministry of Research (1996).

Besides tobacco exposure, factors associated with the development of pre-invasive bronchial lesions are not known. Autofluorescence bronchoscopy was used to assess the prevalence of severe dysplasia and carcinoma in situ (SD/CIS) of the proximal bronchial tree in relation to occupational or nonoccupational carcinogen exposure.

Among the 241 individuals in this study, the overall prevalence of at least one SD/CIS was 9% (21 subjects). Multivariable analysis revealed significant and independent associations between presence of SD/CIS and: 1) active smoking, relative to former smokers; 2) presence of synchronous invasive lung cancer; 3) duration of asbestos exposure and; 4) exposure to other occupational carcinogens.

The independent associations of synchronous lung cancer with severe dysplasia and carcinoma, after adjusting for both occupational and nonoccupational carcinogen exposures, suggest other mechanisms than a field cancerisation may be involved in the carcinogenesis of these pre-invasive lesions. Moreover, active smokers, patients with recently resected invasive lung cancer and workers occupationally exposed to bronchial carcinogens may represent a population of choice for early cancer endoscopic detection programmes in view of their high severe dysplasia and carcinoma prevalence.




This article has been cited by other articles:


Home page
Am. J. Respir. Crit. Care Med.Home page
M. Salaun, R. Sesboue, S. Moreno-Swirc, J. Metayer, S. Bota, J. Bourguignon, and L. Thiberville
Molecular Predictive Factors for Progression of High-Grade Preinvasive Bronchial Lesions
Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 880 - 886.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
G. Loewen, M. Reid, D. Tan, D. Klippenstein, E. Nava, R. Natarajan, and M. Mahoney
Bimodality Lung Cancer Screening in High-Risk Patients: A Preliminary Report
Chest, May 1, 2004; 125(5_suppl): 163S - 164S.
[Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
C. Paris, J. Benichou, and L. Thiberville
Re: Sex-Related Differences in Bronchial Epithelial Changes Associated With Tobacco Smoking
J Natl Cancer Inst, February 5, 2003; 95(3): 242 - 243.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the European Respiratory Society.