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1 Scottish Pulmonary Vascular Unit and 2 Dept of Radiology Western Infirmary, Glasgow, Scotland, UK
CORRESPONDENCE: A.J. Peacock, Scottish Pulmonary Vascular Unit, Level 8 Laboratory, Western Infirmary, Dumbarton Road, Glasgow, G11 6NT, Scotland, UK. Fax: 44 1412116334. E-mail: apeacock@udcf.gla.ac.uk
Keywords: calculated ventricular mass index, Doppler echocardiography, magnetic resonance imaging, noninvasive, pulmonary arterial hypertension
Received: February 20, 2002
Accepted June 25, 2002
Magnetic resonance imaging (MRI) can provide accurate anatomical measurements of the cardiac ventricles. This study investigated whether a calculated ventricular mass index (VMI) would provide an accurate means of estimating pulmonary artery pressure noninvasively, and compared the results with conventional Doppler echocardiography and invasive measurement.
A total of 26 subjects referred for investigation of pulmonary hypertension were studied by MRI and echocardiography within 2 weeks of cardiac catheterisation. The correlations for mean pulmonary artery pressure were as follows: VMI (ratio of right ventricular mass over left ventricular mass) r=0.81; pulmonary artery systolic pressure (echocardiography) r=0.77. The confidence intervals for the VMI were narrower than for echocardiography. Sensitivity and specificity for pulmonary hypertension were 84 and 71% respectively for the VMI compared with 89 and 57% for echocardiography.
The calculated ventricular mass index provides an accurate and practical means of estimating pulmonary artery pressure noninvasively in pulmonary hypertension and may provide a more accurate estimate than Doppler echocardiography. This may be because it reflects the right ventricular response to sustained pulmonary hypertension over a long period and is not influenced by short-term physiological variables affecting echocardiography, such as heart rate, posture, hydration status and oxygen supplementation.
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