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Copenhagen City Heart Study: longitudinal analysis of ventilatory capacity in diabetic and nondiabetic adults

¹ Copenhagen City Heart Study, Bispebjerg University Hospital, Copenhagen, ² Dept of Respiratory Medicine, Hvidovre University Hospital, Hvidovre, and ³ Dept of Biostatistics, University of Copenhagen, Panum Institute, Copenhagen, Denmark

CORRESPONDENCE: P. Lange, Dept of Respiratory Medicine 223, Hvidovre University Hospital, DK-2650, Hvidovre, Denmark. Fax: 45 36323784. E-mail: peter.lange@hh.hosp.dk

Keywords: diabetes mellitus, longitudinal study, lung function

Received: June 12, 2002
Accepted July 22, 2002

The Copenhagen City Heart Study was supported by grants from The Danish Heart Foundation and The Danish Medical Research Council. The analysis of lung function decline in diabetes was supported financially by Pfizer.

The natural history of lung function in diabetes is unknown due to the lack of longitudinal observations.

The decline of forced expiratory volume in one second (FEV₁) and forced vital capacity (FVC) was studied over 15 yrs in the 17,506 adult participants of The Copenhagen City Heart Study, which included 266 individuals with diabetes.

Multiple linear regression and a mixed-effects model were used, taking into account correlation between repeated measurements and adjusting for relevant confounders. In both sexes, FEV₁ and FVC were consistently lower in diabetic individuals, compared with healthy individuals, with an average reduction of 8% of the predicted value. Longitudinal analyses showed that the decline of FEV₁ and FVC in diabetic individuals was similar to that observed in nondiabetic subjects.

It was concluded that although diabetic subjects have, on average, a lower forced expiratory volume in one second and forced vital capacity than individuals without diabetes, this deficit seems not to be progressive in the long term. These observations may be of importance with regard to diabetes treatment with inhaled pulmonary insulin, which is likely to become available within a few years.

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