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Extrinsic allergic alveolitis induced by the yeast Debaryomyces Hansenii

¹ First Dept of Medicine, Asahikawa Medical College and ² Dept of Respiratory Medicine, National Douhoku Hospital, Hanasaki, Asahikawa, Japan

CORRESPONDENCE: Y. Yamamoto, First Dept of Medicine, Asahikawa Medical College, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, 078-8510, Japan. Fax: 81 166682449. E-mail: yasushiy@asahikawa.hosp.go.jp

Keywords: air conditioning, alveolitis, extrinsic allergic, inhalation exposure, Debaryomyces Hansenii

Received: April 13, 2002
Accepted April 29, 2002

Abstract

A 65-yr-old female developed cough, fever and dyspnoea following repeated exposure to a home ultrasonic humidifier. High-resolution computed tomography showed ground-glass opacity in both lung fields. Arterial blood gas analysis gave an oxygen tension of 8.38 kPa (63 Torr). Pulmonary function testing revealed restrictive ventilatory impairment with a reduction in the diffusing capacity. The diagnosis of extrinsic allergic alveolitis (EAA) was confirmed by radiographic findings, pathological evidence of alveolitis and reproductive development by a provocation test to the humidifier water. The yeast Debaryomyces Hansenii was the only microorganism cultured from the water of the humidifier. The double diffusion precipitating test and lymphocyte proliferative response was positive for an extract of D. Hansenii, providing evidence to incriminate this fungus. This is the first described case of EAA caused by D. Hansenii.

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