|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2002
The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis
1 Dept of Internal Medicine, 3 Data Centre, and 4 Service of Pathology, Jules Bordet Institute, Brussels, Belgium. 2 Service of Pneumology and Thoracic Medicine, CHU Calmette, Lille, France
CORRESPONDENCE: A-P. Meert, Institut Jules Bordet, 1, rue Héger Bordet, 1000-Bruxelles, Belgium. Fax: 32 25343756. E-mail: ap.meert@bordet.be
Keywords: epidermal growth factor receptor, lung cancer, systematic review
Received: November 19, 2001
Accepted June 18, 2002
This study was supported by an FNRS-Télévie grant (7.4512.98), Belgium. A-P. Meert is an FNRS research fellow.
The prognostic value of epidermal growth factor receptor (EGF-R) for survival of patients with lung cancer remains controversial. The authors performed a systematic review of the literature in order to clarify its impact.
Published studies were identified using an electronic search in order to aggregate the available survival results, after a methodological assessment using a scale specifically designed by the European Lung Cancer Working Party (ELCWP). To be eligible, a study had to have dealt with EGF-R assessment in lung cancer patients on the primary site and to have analysed survival according to EGF-R expression.
Among the 16 eligible studies, 14 assessed any nonsmall-cell lung cancer (NSCLC) subtype, one adenocarcinoma only and one squamous-cell carcinoma only. The overall median quality score was 56.3%, with no significant difference either between studies assessable or not assessable for meta-analysis or between studies with significant and nonsignificant results. One individual trial reported a survival benefit for patients with EGF-R expression, three a survival disadvantage and 12 no statistically significant difference. Eleven studies (2,185 patients) provided sufficient data to allow a meta-analysis of the survival results. EGF-R expression positivity was determined according to the cut-off as determined by the authors. The meta-analysis showed that EGF-R expression was not a statistically significant prognostic factor for survival in NSCLC. In the subgroup of studies using immunohistochemistry, statistical tests reached a significant level against EGF-R.
Epidermal growth factor receptor might be a poor prognostic factor for survival in nonsmall-cell lung cancer. The amplitude of the impact is small, however, and may be subject to publication bias.
This article has been cited by other articles:
|
|
 |
|
  N. Peled, K. Yoshida, M. W. Wynes, and F. R. Hirsch Review: Predictive and prognostic markers for epidermal growth factor receptor inhibitor therapy in non-small cell lung cancer Therapeutic Advances in Medical Oncology, November 1, 2009; 1(3): 137 - 144. [Abstract] [PDF]
|
|
|
|
 |
|
 V. Ludovini, G. Bellezza, L. Pistola, F. Bianconi, L. Di Carlo, A. Sidoni, A. Semeraro, R. Del Sordo, F. R. Tofanetti, M. G. Mameli, et al. High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients Ann. Onc., May 1, 2009; 20(5): 842 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yamamoto, Y. Yamada, Y. Fujiwara, K. Yamada, Y. Fujisaka, T. Shimizu, and T. Tamura Phase I and Pharmacokinetic Study of HER2-targeted rhuMAb 2C4 (Pertuzumab, RO4368451) in Japanese Patients with Solid Tumors Jpn. J. Clin. Oncol., April 1, 2009; 39(4): 260 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Sculier Prognostic Factors and Implications of Positron Emission Tomography ASCO Educational Book, January 1, 2009; 2009(1): 469 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-Q. Zhu, G. da Cunha Santos, K. Ding, A. Sakurada, J.-C. Cutz, N. Liu, T. Zhang, P. Marrano, M. Whitehead, J. A. Squire, et al. Role of KRAS and EGFR As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21 J. Clin. Oncol., September 10, 2008; 26(26): 4268 - 4275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Van Dyke, M. L. Cote, G. M. Prysak, G. B. Claeys, A. S. Wenzlaff, V. C. Murphy, F. Lonardo, and A. G. Schwartz COX-2/EGFR expression and survival among women with adenocarcinoma of the lung Carcinogenesis, September 1, 2008; 29(9): 1781 - 1787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kelly, K. Chansky, L. E. Gaspar, K. S. Albain, J. Jett, Y. C. Ung, D. H.M. Lau, J. J. Crowley, and D. R. Gandara Phase III Trial of Maintenance Gefitinib or Placebo After Concurrent Chemoradiotherapy and Docetaxel Consolidation in Inoperable Stage III Non-Small-Cell Lung Cancer: SWOG S0023 J. Clin. Oncol., May 20, 2008; 26(15): 2450 - 2456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Hodkinson, A. MacKinnon, and T. Sethi Targeting Growth Factors in Lung Cancer Chest, May 1, 2008; 133(5): 1209 - 1216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Sarkaria, M. F. Zakowski, D. Pham, M. Hezel, M. I. Ebright, S. Chuai, E. S. Venkatraman, M. G. Kris, V. W. Rusch, and B. Singh Epidermal Growth Factor Receptor Signaling in Adenocarcinomas With Bronchioloalveolar Components Ann. Thorac. Surg., January 1, 2008; 85(1): 216 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Schwartz and D. E. Henson Diagnostic Surgical Pathology in Lung Cancer: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition) Chest, September 1, 2007; 132(3_suppl): 78S - 93S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Karamouzis, J. R. Grandis, and A. Argiris Therapies Directed Against Epidermal Growth Factor Receptor in Aerodigestive Carcinomas JAMA, July 4, 2007; 298(1): 70 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Taillade, F Penault-Llorca, T Boulet, P Fouret, S Michiels, E Taranchon, G Mountzios, P Validire, J Domont, P Girard, et al. Immunohistochemichal expression of biomarkers: a comparative study between diagnostic bronchial biopsies and surgical specimens of non-small-cell lung cancer Ann. Onc., June 1, 2007; 18(6): 1043 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Gatzemeier, A. Pluzanska, A. Szczesna, E. Kaukel, J. Roubec, F. De Rosa, J. Milanowski, H. Karnicka-Mlodkowski, M. Pesek, P. Serwatowski, et al. Phase III Study of Erlotinib in Combination With Cisplatin and Gemcitabine in Advanced Non-Small-Cell Lung Cancer: The Tarceva Lung Cancer Investigation Trial J. Clin. Oncol., April 20, 2007; 25(12): 1545 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Dziadziuszko, B Holm, B. Skov, K Osterlind, M. Sellers, W. Franklin, P. Bunn Jr, M Varella-Garcia, and F. Hirsch Epidermal growth factor receptor gene copy number and protein level are not associated with outcome of non-small-cell lung cancer patients treated with chemotherapy Ann. Onc., March 1, 2007; 18(3): 447 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Kyzas, D. Denaxa-Kyza, and J. P. A. Ioannidis Quality of Reporting of Cancer Prognostic Marker Studies: Association With Reported Prognostic Effect J Natl Cancer Inst, February 7, 2007; 99(3): 236 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Berghmans, M Paesmans, C Mascaux, B Martin, A-P Meert, A Haller, J-J Lafitte, and J-P Sculier Thyroid transcription factor 1--a new prognostic factor in lung cancer: a meta-analysis Ann. Onc., November 1, 2006; 17(11): 1673 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C-Q Zhu, W Shih, C-H Ling, and M-S Tsao Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation. J. Clin. Pathol., August 1, 2006; 59(8): 790 - 800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Dziadziuszko, F. R. Hirsch, M. Varella-Garcia, and P. A. Bunn Jr. Selecting Lung Cancer Patients for Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors by Immunohistochemistry and Fluorescence In situ Hybridization--Why, When, and How? Clin. Cancer Res., July 15, 2006; 12(14): 4409s - 4415s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Bunn Jr., R. Dziadziuszko, M. Varella-Garcia, W. A. Franklin, S. E. Witta, K. Kelly, and F. R. Hirsch Biological Markers for Non-Small Cell Lung Cancer Patient Selection for Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy. Clin. Cancer Res., June 15, 2006; 12(12): 3652 - 3656. [Full Text] [PDF]
|
|
|
|
 |
|
 H Nakamura, N Kawasaki, M Taguchi, and K Kabasawa Survival impact of epidermal growth factor receptor overexpression in patients with non-small cell lung cancer: a meta-analysis Thorax, February 1, 2006; 61(2): 140 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Thienelt, P. A. Bunn Jr, N. Hanna, A. Rosenberg, M. N. Needle, M. E. Long, D. L. Gustafson, and K. Kelly Multicenter Phase I/II Study of Cetuximab With Paclitaxel and Carboplatin in Untreated Patients With Stage IV Non-Small-Cell Lung Cancer J. Clin. Oncol., December 1, 2005; 23(34): 8786 - 8793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kanazawa, K. Yamaguchi, Y. Kinoshita, M. Muramatsu, Y. Komiyama, and S. Nomura Gefitinib Affects Functions of Platelets and Blood Vesselsvia Changes in Prostanoids Balance Clinical and Applied Thrombosis/Hemostasis, October 1, 2005; 11(4): 429 - 434. [Abstract] [PDF]
|
|
|
|
|
|
P. A. Kyzas, K. T. Loizou, and J. P. A. Ioannidis Selective Reporting Biases in Cancer Prognostic Factor Studies J Natl Cancer Inst, July 20, 2005; 97(14): 1043 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Friess, W. Scheuer, and M. Hasmann Combination Treatment with Erlotinib and Pertuzumab against Human Tumor Xenografts Is Superior to Monotherapy Clin. Cancer Res., July 15, 2005; 11(14): 5300 - 5309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Tsao, A. Sakurada, J.-C. Cutz, C.-Q. Zhu, S. Kamel-Reid, J. Squire, I. Lorimer, T. Zhang, N. Liu, M. Daneshmand, et al. Erlotinib in Lung Cancer -- Molecular and Clinical Predictors of Outcome N. Engl. J. Med., July 14, 2005; 353(2): 133 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zheng, G. Bepler, A. Cantor, and E. B. Haura Small Tumor Size and Limited Smoking History Predicts Activated Epidermal Growth Factor Receptor in Early-Stage Non-small Cell Lung Cancer Chest, July 1, 2005; 128(1): 308 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Agus, M. S. Gordon, C. Taylor, R. B. Natale, B. Karlan, D. S. Mendelson, M. F. Press, D. E. Allison, M. X. Sliwkowski, G. Lieberman, et al. Phase I Clinical Study of Pertuzumab, a Novel HER Dimerization Inhibitor, in Patients With Advanced Cancer J. Clin. Oncol., April 10, 2005; 23(11): 2534 - 2543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Herbst, D. H. Johnson, E. Mininberg, D. P. Carbone, T. Henderson, E. S. Kim, G. Blumenschein Jr, J. J. Lee, D. D. Liu, M. T. Truong, et al. Phase I/II Trial Evaluating the Anti-Vascular Endothelial Growth Factor Monoclonal Antibody Bevacizumab in Combination With the HER-1/Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib for Patients With Recurrent Non-Small-Cell Lung Cancer J. Clin. Oncol., April 10, 2005; 23(11): 2544 - 2555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Berghmans, A. P. Meert, B. Martin, V. Ninane, and J. P. Sculier Prognostic role of epidermal growth factor receptor in stage III nonsmall cell lung cancer Eur. Respir. J., February 1, 2005; 25(2): 329 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F Singer, G. Hudelist, W. Lamm, R. Mueller, K. Czerwenka, and E. Kubista Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors Endocr. Relat. Cancer, December 1, 2004; 11(4): 861 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Haringhuizen, H. van Tinteren, H. F. R. Vaessen, P. Baas, and N. van Zandwijk Gefitinib as a last treatment option for non-small-cell lung cancer: durable disease control in a subset of patients Ann. Onc., May 1, 2004; 15(5): 786 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Selvaggi, S. Novello, V. Torri, E. Leonardo, P. De Giuli, P. Borasio, C. Mossetti, F. Ardissone, P. Lausi, and G. V. Scagliotti Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer Ann. Onc., January 1, 2004; 15(1): 28 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. K. Pryer, L. B. Lee, R. Zadovaskaya, X. Yu, J. Sukbuntherng, J. M. Cherrington, and C. A. London Proof of Target for SU11654: Inhibition of KIT Phosphorylation in Canine Mast Cell Tumors Clin. Cancer Res., November 15, 2003; 9(15): 5729 - 5734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A-P. Meert, J-M. Verdebout, B. Martin, V. Ninane, F. Feoli, and J-P. Sculier Epidermal growth factor receptor expression in pre-invasive and early invasive bronchial lesions Eur. Respir. J., April 1, 2003; 21(4): 611 - 615. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |