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Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial

¹ Hospital Therapeutic Clinic, Pavlov Medical University, St-Petersburg, Russia. ² Dept of Thoracic Medicine, National Heart and Lung Institute, London, UK

CORRESPONDENCE: A. Emelyanov, Hospital Therapeutic Clinic, Pavlov Medical University, 6/8 L.Tolstogo Str, St-Petersburg, 197089, Russia. Fax: 7 8122342749. E-mail: emelav@netscape.net

Keywords: asthma, green-lipped mussel, lipid extract, treatment

Received: December 19, 2001
Accepted April 18, 2002

Asthma is a chronic inflammatory disease of the airways mediated, at least in part, by leukotrienes and other lipid mediators. Experimental studies have shown that lipid extract of New Zealand green-lipped mussel, Perna canaliculus, is effective in inhibiting 5'-lipoxygenase and cyclo-oxygenase pathways responsible for production of eicosanoids, including leukotrienes and prostaglandins. The aim of this study was to assess its effect on symptoms, peak expiratory flow (PEF) and hydrogen peroxide (H₂O₂) in expired breath condensate as a marker of airway inflammation in patients with steroid-naïve atopic asthma in a double-blind randomised, placebo-controlled clinical trial.

Forty six patients with atopic asthma received two capsules of lipid extract (Lyprinol®) or placebo b.i.d. for 8 weeks. Each capsule of lipid extract contained 50 mg -3 polyunsaturated fatty acids and 100 mg olive oil, whereas placebo capsules contained only 150 mg olive oil.

There was a significant decrease in daytime wheeze, the concentration of exhaled H₂O₂ and an increase in morning PEF in the lipid extract group compared to the placebo group. There were no significant side-effects.

The authors conclude that lipid extract of New Zealand green-lipped mussel may have some beneficial effect in patients with atopic asthma.

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