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2 Respiratory Unit and 4 Ergonomics Dept, Istituto Scientifico di Montescano and Respiratory Units, Istituto Scientifico di, 3 Gussago and 1 Pavia, Fondazione S. Maugeri Istituto Ricovero e Cura a Carattere Scientifico, Pavia, Italy
CORRESPONDENCE: S. Nava, Respiratory Unit, Fondazione S.Maugeri, Via Ferrata 8, 27100, Pavia, Italy. Fax: 39 0382592075. E-mail: snava@fsm.it
Keywords: lung rejection, phrenic nerve stimulation, respiratory muscle, skeletal muscle, weakness
Received: February 28, 2002
Accepted March 11, 2002
Abstract
There have been occasional reports of acute respiratory and skeletal muscle weakness in intensive care unit patients treated with massive doses of corticosteroids. However, in this setting the concomitant use of other drugs may have influenced the finding.
In this study the effects of 5 days of treatment with high doses of steroids in consecutive patients with acute lung rejection after transplantation were systematically evaluated. Maximal inspiratory pressure during phrenic nerve stimulation and peak torque of isokinetic contraction of the quadriceps and hamstring muscles were measured objectively.
Compared to the pretreatment condition,
This demonstrates muscle weakness induced by steroids within patients.
45% of patients showed acute generalised muscle weakness that recovered after 2 months.
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