|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2002
Weakness of respiratory and skeletal muscles after a short course of steroids in patients with acute lung rejection
2 Respiratory Unit and 4 Ergonomics Dept, Istituto Scientifico di Montescano and Respiratory Units, Istituto Scientifico di, 3 Gussago and 1 Pavia, Fondazione S. Maugeri Istituto Ricovero e Cura a Carattere Scientifico, Pavia, Italy
CORRESPONDENCE: S. Nava, Respiratory Unit, Fondazione S.Maugeri, Via Ferrata 8, 27100, Pavia, Italy. Fax: 39 0382592075. E-mail: snava@fsm.it
Keywords: lung rejection, phrenic nerve stimulation, respiratory muscle, skeletal muscle, weakness
Received: February 28, 2002
Accepted March 11, 2002
Abstract
There have been occasional reports of acute respiratory and skeletal muscle weakness in intensive care unit patients treated with massive doses of corticosteroids. However, in this setting the concomitant use of other drugs may have influenced the finding.
In this study the effects of 5 days of treatment with high doses of steroids in consecutive patients with acute lung rejection after transplantation were systematically evaluated. Maximal inspiratory pressure during phrenic nerve stimulation and peak torque of isokinetic contraction of the quadriceps and hamstring muscles were measured objectively.
Compared to the pretreatment condition,
This demonstrates muscle weakness induced by steroids within patients.
45% of patients showed acute generalised muscle weakness that recovered after 2 months.
This article has been cited by other articles:
|
|
 |
|
  D. S. Hui, K. T. Wong, F. W. Ko, L. S. Tam, D. P. Chan, J. Woo, and J. J.Y. Sung The 1-Year Impact of Severe Acute Respiratory Syndrome on Pulmonary Function, Exercise Capacity, and Quality of Life in a Cohort of Survivors Chest, October 1, 2005; 128(4): 2247 - 2261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D S Hui, G M Joynt, K T Wong, C D Gomersall, T S Li, G Antonio, F W Ko, M C Chan, D P Chan, M W Tong, et al. Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors Thorax, May 1, 2005; 60(5): 401 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Pinet, P Scillia, M Cassart, M Lamotte, C Knoop, C Melot, and M Estenne Preferential reduction of quadriceps over respiratory muscle strength and bulk after lung transplantation for cystic fibrosis Thorax, September 1, 2004; 59(9): 783 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N.S. Hopkinson, W.D-C. Man, M.J. Dayer, E.T. Ross, A.H. Nickol, N. Hart, J. Moxham, and M.I. Polkey Acute effect of oral steroids on muscle function in chronic obstructive pulmonary disease Eur. Respir. J., July 1, 2004; 24(1): 137 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Laghi and M. J. Tobin Disorders of the Respiratory Muscles Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 10 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zanotti, G. Felicetti, M. Maini, and C. Fracchia Peripheral Muscle Strength Training in Bed-Bound Patients With COPD Receiving Mechanical Ventilation: Effect of Electrical Stimulation Chest, July 1, 2003; 124(1): 292 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nava From the Author Eur. Respir. J., February 1, 2003; 21(2): 378 - 378. [Full Text] [PDF]
|
|
|
|
|
|
C.D. Shee Muscle weakness after short course of steroids Eur. Respir. J., February 1, 2003; 21(2): 377 - 378. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |