HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (42) Citing Articles via Google Scholar Google Scholar Articles by Polosa, R. Search for Related Content PubMed PubMed Citation Articles by Polosa, R.

Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease

Dept of Internal and Specialist Medicine, University of Catania, Ascoli-Tomaselli Hospitals, Catania, Italy

CORRESPONDENCE: R. Polosa, Dipartimento di Medicina Interna e Specialistica, Università di Catania Ospedale Tomaselli, Via Passo Gravina 187, 95125, Catania, Italy. Fax: 39 095330707. E-mail: rp5@soton.ac.uk

Keywords: adenosine receptors, asthma, bronchoconstriction, chronic obstructive pulmonary disease, mast cell

Received: February 12, 2002
Accepted March 26, 2002

Abstract

Adenosine administration by inhalation elicits concentration-related bronchoconstriction in subjects with asthma and chronic obstructive pulmonary disease (COPD). The mechanisms of adenosine-induced bronchoconstriction appear to involve a selective interaction with activated mast cells with subsequent release of preformed and newly-formed mediators. Further evidence linking adenosine signalling to asthma and COPD comes from the finding that many cell types that play important roles in the exacerbation of these conditions express adenosine receptors and demonstrate relevant effects through stimulation of these receptors.

Therefore, blockade of these receptors may be a valuable approach to the treatment of asthma and chronic obstructive pulmonary disease. Promising adenosine-receptor targets for novel therapeutics of asthma and chronic obstructive pulmonary disease have recently been identified in a number of inflammatory cell types, including mast cells, eosinophils, lymphocytes, neutrophils, and macrophages. The recent characterisation of the A_2B receptors indicates the human lung mast cell as one of the most strategic cellular targets.

This article has been cited by other articles:

				S. J. Mustafa, A. Nadeem, M. Fan, H. Zhong, L. Belardinelli, and D. Zeng Effect of a Specific and Selective A2B Adenosine Receptor Antagonist on Adenosine Agonist AMP and Allergen-Induced Airway Responsiveness and Cellular Influx in a Mouse Model of Asthma J. Pharmacol. Exp. Ther., March 1, 2007; 320(3): 1246 - 1251. [Abstract] [Full Text] [PDF]

				K. Varani, G. Caramori, F. Vincenzi, I. Adcock, P. Casolari, E. Leung, S. MacLennan, S. Gessi, S. Morello, P. J. Barnes, et al. Alteration of Adenosine Receptors in Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 398 - 406. [Abstract] [Full Text] [PDF]

				P. C. M. Obiefuna, V. K. Batra, A. Nadeem, P. Borron, C. N. Wilson, and S. J. Mustafa A Novel A1 Adenosine Receptor Antagonist, L-97-1 [3-[2-(4-Aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], Reduces Allergic Responses to House Dust Mite in an Allergic Rabbit Model of Asthma J. Pharmacol. Exp. Ther., October 1, 2005; 315(1): 329 - 336. [Abstract] [Full Text] [PDF]

				P. J. Oldenburg and S. J. Mustafa Involvement of Mast Cells in Adenosine-Mediated Bronchoconstriction and Inflammation in an Allergic Mouse Model J. Pharmacol. Exp. Ther., April 1, 2005; 313(1): 319 - 324. [Abstract] [Full Text] [PDF]

				L. C. Denlinger, G. Angelini, K. Schell, D. N. Green, A. G. Guadarrama, U. Prabhu, D. B. Coursin, P. J. Bertics, and K. Hogan Detection of Human P2X7 Nucleotide Receptor Polymorphisms by a Novel Monocyte Pore Assay Predictive of Alterations in Lipopolysaccharide-Induced Cytokine Production J. Immunol., April 1, 2005; 174(7): 4424 - 4431. [Abstract] [Full Text] [PDF]

				B. Luijk, R.D. Kempsford, A.M. Wright, P. Zanen, and J-W.J. Lammers Duration of effect of single-dose inhaled fluticasone propionate on AMP-induced bronchoconstriction Eur. Respir. J., April 1, 2004; 23(4): 559 - 564. [Abstract] [Full Text] [PDF]

				H. Zhong, L. Belardinelli, T. Maa, I. Feoktistov, I. Biaggioni, and D. Zeng A2B Adenosine Receptors Increase Cytokine Release by Bronchial Smooth Muscle Cells Am. J. Respir. Cell Mol. Biol., January 1, 2004; 30(1): 118 - 125. [Abstract] [Full Text] [PDF]

				N. D. Khoa, M. C. Montesinos, A. J. Williams, M. Kelly, and B. N. Cronstein Th1 Cytokines Regulate Adenosine Receptors and Their Downstream Signaling Elements in Human Microvascular Endothelial Cells J. Immunol., October 15, 2003; 171(8): 3991 - 3998. [Abstract] [Full Text] [PDF]

				L. Spicuzza, G.U. Di Maria, and R. Polosa Adenosine levels in the exhaled breath condensate: a potential surrogate marker of airway inflammation Eur. Respir. J., August 1, 2003; 22(2): 392 - 392. [Full Text] [PDF]