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Correlation of inhaled nitric-oxide induced reduction of pulmonary artery pressure and vascular changes

Depts of ¹ Anaesthesiology and the Intensive Care Unit, ² Physiology and ³ Paediatrics, Faculty of Medicine, University of Mie, Edobashi, Tsu, Mie, Japan

CORRESPONDENCE: K. Maruyama, Dept of Anaesthesiology, Mie University School of Medicine, 2-174, Edobashi, Tsu, Mie, Japan, 514-8507. Fax: 81 592315227. E-mail: k-maru@clin.medic.mie-u.ac.jp

Keywords: hypoxia, nitric oxide, pulmonary hypertension, vascular remodelling

Received: June 1, 2001
Accepted January 14, 2002

This study was supported in part by Grants-In-Aid for Scientific Research 09470326, 12470319, and 13877256 from the Japanese Ministry of Education, Science and Culture, and a Grant for Paediatric Research from the Ministry of Health and Welfare.

The purpose of the present study was to determine the relationship between hypertensive pulmonary vascular remodelling and the changes in mean pulmonary artery pressure (mPAP) during low-dose nitric oxide (NO) inhalation.

Rats were exposed to chronic hypobaric hypoxia (air at 50.5 kPa (380 mmHg), 10% oxygen, for 5–29 days) to induce chronic pulmonary hypertension (PH) with pulmonary vascular structural changes. After the chronic hypoxic exposure, the rats had an indwelling pulmonary artery catheter inserted and changes in mPAP with NO were correlated to morphometrical analysis of pulmonary vascular changes.

All concentrations of inhaled NO (0.1–2.0 parts per million) reduced mPAP with a similar per cent reduction from baseline mPAP in PH rats, while no changes were observed in control rats. During NO inhalation in PH rats, the absolute value of the decrease in mPAP, but not per cent reduction in mPAP, significantly correlated with baseline mPAP, the percentage of muscularised arteries at the alveolar wall level and at the alveolar duct level, and the per cent medial wall thickness of muscularised arteries.

In the chronic hypoxic pulmonary hypertension model, the severity of pulmonary vascular remodelling did not alter the reactivity of the pulmonary arteries to nitric oxide and might, in part, determine the magnitude of nitric-oxide induced absolute reduction in mean pulmonary artery pressure.

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				B. H. Jiang, J. Maruyama, A. Yokochi, M. Iwasaki, H. Amano, Y. Mitani, and K. Maruyama Prolonged Nitric Oxide Inhalation Fails to Regress Hypoxic Vascular Remodeling in Rat Lung Chest, June 1, 2004; 125(6): 2247 - 2252. [Abstract] [Full Text] [PDF]