ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (29)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beeh, K.M.
Right arrow Articles by Buhl, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beeh, K.M.
Right arrow Articles by Buhl, R.
Eur Respir J 2002; 19:1119-1123
Copyright ©ERS Journals Ltd 2002


Glutathione deficiency of the lower respiratory tract in patients with idiopathic pulmonary fibrosis

K.M. Beeh, J. Beier, I.C. Haas, O. Kornmann, P. Micke and R. Buhl

Pulmonary Dept, Internal Medicine, University Hospital Mainz, Mainz, Germany

CORRESPONDENCE: K.M. Beeh, Pulmonary Dept, Internal Medicine, University Hospital, Langenbeckstr. 1, 55131, Mainz, Germany. Fax: 49 161311175661. E-mail: k.beeh@3-med.klinik.uni-mainz.de

Keywords: antioxidants, glutathione, induced sputum, pulmonary fibrosis

Received: July 19, 2001
Accepted February 10, 2002

Idiopathic pulmonary fibrosis (IPF) is a disease of unknown aetiology. Increased oxidant burden and antioxidant, e.g. glutathione (GSH), deficiency in the lower respiratory tract have been thought to play a role in the progression of IPF. Sputum induction is a safe noninvasive tool to study inflammation in the respiratory tract.

The aim of the present study was to evaluate the direct measurement of GSH in induced sputum supernatant. Sixteen IPF patients and 15 healthy, nonsmoking subjects underwent sputum induction. Total GSH in sputum, saliva and plasma was measured spectrophotometrically.

Sputum GSH was decreased more then four-fold in IPF patients when compared to healthy subjects (mean GSH 1.4±0.34 µM versus 5.8±0.98 µM). Salivary GSH was generally low or undetectable in all subjects. Plasma GSH levels were lower in IPF patients (0.26±0.1 versus 0.74±0.16 µM). In IPF patients, there was a borderline correlation of sputum GSH levels with disease duration and lung-function impairment.

These data confirm the established role of oxidant/antioxidant imbalance in the pathogenesis of idiopathic pulmonary fibrosis, and show the potential of induced sputum to directly study inflammatory processes and surrogate markers in interstitial lung diseases like idiopathic pulmonary fibrosis.




This article has been cited by other articles:


Home page
Therapeutic Advances in Respiratory DiseaseHome page
P. Rogliani, M. Mura, M. Assunta Porretta, and C. Saltini
Review: New perspectives in the treatment of idiopathic pulmonary fibrosis
Therapeutic Advances in Respiratory Disease, April 1, 2008; 2(2): 75 - 93.
[Abstract] [PDF]


Home page
Eur Respir JHome page
I. Romieu, F. Castro-Giner, N. Kunzli, and J. Sunyer
Air pollution, oxidative stress and dietary supplementation: a review
Eur. Respir. J., January 1, 2008; 31(1): 179 - 197.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Ramirez, B. Ramadan, J. D. Ritzenthaler, H. N. Rivera, D. P. Jones, and J. Roman
Extracellular cysteine/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta
Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L972 - L981.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
M. Y. Yeh, E. L. Burnham, M. Moss, and L. A. S. Brown
Chronic Alcoholism Alters Systemic and Pulmonary Glutathione Redox Status
Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 270 - 276.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
I. Rahman and I. M. Adcock
Oxidative stress and redox regulation of lung inflammation in COPD.
Eur. Respir. J., July 1, 2006; 28(1): 219 - 242.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
K. M. Beeh, J. Beier, N. Koppenhoefer, and R. Buhl
Increased Glutathione Disulfide and Nitrosothiols in Sputum Supernatant of Patients With Stable COPD
Chest, October 1, 2004; 126(4): 1116 - 1122.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
M. Corradi, G. Folesani, R. Andreoli, P. Manini, A. Bodini, G. Piacentini, S. Carraro, S. Zanconato, and E. Baraldi
Aldehydes and Glutathione in Exhaled Breath Condensate of Children with Asthma Exacerbation
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 395 - 399.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
S. El-Chemaly, M. Salathe, S. Baier, G. E. Conner, and R. Forteza
Hydrogen Peroxide-Scavenging Properties of Normal Human Airway Secretions
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 425 - 430.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the European Respiratory Society.