HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Schweitzer, C. Articles by Marchal, F. Search for Related Content PubMed PubMed Citation Articles by Schweitzer, C. Articles by Marchal, F.

Respiratory impedance response to a deep inhalation in asthmatic children with spontaneous airway obstruction

Laboratoire d'Explorations Fonctionnelles Pédiatriques, Hôpital d'Enfants, Centre Hospitalier Universitaire de Nancy, Vandoeuvre, France

CORRESPONDENCE: F. Marchal, Laboratoire de Physiologie, Faculté de Médecine, Avenue de la Forêt de Haye, F-54505, Vandoeuvre les Nancy, France. Fax: 33 383592726. E-mail: f.marchal@chu-nancy.fr

Keywords: asthma, deep inhalation, forced oscillation technique, head generator, paediatric lung function, respiratory resistance and reactance

Received: July 6, 2001
Accepted January 12, 2002

This study was supported by EA 3450 "Interactions des systèmes de régulation respiratoire chez l'adulte et l'enfant".

The aim of the study was to determine whether the bronchomotor effect of a deep inhalation (DI) may be detected during tidal breathing in asthmatic children with spontaneous airway obstruction (AO).

Two groups of children aged 5–15 yrs were studied. AO was mild in group 1 (n=12, forced expiratory volume in one second (FEV₁) 75% predicted) and moderate-to-severe in group 2 (n=9, FEV₁ 70% pred). The forced oscillation technique at 12 Hz using a head generator allowed the determination of respiratory resistance in inspiration (R_rsi) and expiration (R_rse) before and after DI, at baseline and after salbutamol.

At baseline, R_rsi but not R_rse was found to decrease significantly after DI in group 1 but not in group 2. The change induced by DI was significantly different in group 1 (–1.5±0.5 hPa·s·L^–1) compared to group 2 (0.5±0.5 hPa·s·L^–1) and exhibited significant negative correlation to FEV₁ % pred. After salbutamol, DI had no effect.

In conclusion, asthmatic children show a bronchomotor response to deep inhalation that depends on the degree of airway obstruction. The effect is more readily demonstrated in inspiration than in expiration.

This article has been cited by other articles:

				A. M. Slats, K. Janssen, A. van Schadewijk, D. T. van der Plas, R. Schot, J. G. van den Aardweg, J. C. de Jongste, P. S. Hiemstra, T. Mauad, K. F. Rabe, et al. Bronchial Inflammation and Airway Responses to Deep Inspiration in Asthma and Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 121 - 128. [Abstract] [Full Text] [PDF]

				E. Oostveen, D. MacLeod, H. Lorino, R. Farre, Z. Hantos, K. Desager, and F. Marchal The forced oscillation technique in clinical practice: methodology, recommendations and future developments Eur. Respir. J., December 1, 2003; 22(6): 1026 - 1041. [Abstract] [Full Text] [PDF]