HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Merkus, P.J.F.M. Articles by de Jongste, J.C. Search for Related Content PubMed PubMed Citation Articles by Merkus, P.J.F.M. Articles by de Jongste, J.C.

Annual lung function changes in young patients with chronic lung disease

Dept of Paediatrics, Subdivision of Respiratory Medicine, Erasmus Medical Centre Rotterdam, Children's Hospital, Rotterdam, The Netherlands

CORRESPONDENCE: P.J.F.M. Merkus, Sophia Children's Hospital, Erasmus Medical Centre Rotterdam, PO Box 2060, 3000 CB, Rotterdam, the Netherlands. Fax: 31 104636772. E-mail: merkus@alkg.azr.nl

Keywords: adolescents, chronic lung disease, cystic fibrosis, follow-up, growth spurt, ventilatory function reference equations

Received: June 22, 2001
Accepted November 5, 2001

Reference equations for ventilatory function that use different statistical models may introduce artifacts that affect the estimated change of lung function during growth in young subjects. The effect of differently modelled reference equations on the estimated annual change of forced expiratory volume in one second (FEV₁) and forced vital capacity (FVC) in young patients with chronic lung disease was assessed.

Four frequently used reference equations were used to describe the longitudinal changes of FEV₁ and FVC in 52 patients (23 females) with cystic fibrosis (CF) during a mean follow-up of 3.9 yrs.

Choice of reference equations directly affected value and, most importantly, estimated annual change of FVC and FEV₁. Mean±sd annual change of FEV₁ varied from 2.2±6.2 to –2.2±3.6% of predicted. For two reference equations the estimated individual changes of FEV₁ and FVC in CF were positively correlated with mean individual age. This probably reflects underestimation of deteriorating lung function.

Variability of annual change was independent of age only when reference equations that were designed to accurately predict lung function during the pubertal growth spurt were used. These findings have implications for patient care and clinical research.

This article has been cited by other articles:

				S. Stanojevic, A. Wade, J. Stocks, J. Hankinson, A. L. Coates, H. Pan, M. Rosenthal, M. Corey, P. Lebecque, and T. J. Cole Reference Ranges for Spirometry Across All Ages: A New Approach Am. J. Respir. Crit. Care Med., February 1, 2008; 177(3): 253 - 260. [Abstract] [Full Text] [PDF]

				N. Beydon, S. D. Davis, E. Lombardi, J. L. Allen, H. G. M. Arets, P. Aurora, H. Bisgaard, G. M. Davis, F. M. Ducharme, H. Eigen, et al. An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1304 - 1345. [Full Text] [PDF]

				L. L. Vanscoy, S. M. Blackman, J. M. Collaco, A. Bowers, T. Lai, K. Naughton, M. Algire, R. McWilliams, S. Beck, J. Hoover-Fong, et al. Heritability of Lung Disease Severity in Cystic Fibrosis Am. J. Respir. Crit. Care Med., May 15, 2007; 175(10): 1036 - 1043. [Abstract] [Full Text] [PDF]

				A Clement, A Tamalet, E Leroux, S Ravilly, B Fauroux, and J-P Jais Long term effects of azithromycin in patients with cystic fibrosis: a double blind, placebo controlled trial Thorax, October 1, 2006; 61(10): 895 - 902. [Abstract] [Full Text] [PDF]

				J Twiss, A W Stewart, and C A Byrnes Longitudinal pulmonary function of childhood bronchiectasis and comparison with cystic fibrosis Thorax, May 1, 2006; 61(5): 414 - 418. [Abstract] [Full Text] [PDF]

				C Que, P Cullinan, and D Geddes Improving rate of decline of FEV1 in young adults with cystic fibrosis Thorax, February 1, 2006; 61(2): 155 - 157. [Abstract] [Full Text] [PDF]

				M. Kulich, M. Rosenfeld, J. Campbell, R. Kronmal, R. L. Gibson, C. H. Goss, and B. Ramsey Disease-specific Reference Equations for Lung Function in Patients with Cystic Fibrosis Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 885 - 891. [Abstract] [Full Text] [PDF]

				P.J.F.M. Merkus, W. van Pelt, J.C. van Houwelingen, L.E.M. van Essen-Zandvliet, E.J. Duiverman, K.F. Kerrebijn, and P.H. Quanjer Inhaled corticosteroids and growth of airway function in asthmatic children Eur. Respir. J., June 1, 2004; 23(6): 861 - 868. [Abstract] [Full Text] [PDF]

				P.A. de Jong, Y. Nakano, M.H. Lequin, J.R Mayo, R. Woods, P.D. Pare, and H.A.W.M. Tiddens Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis Eur. Respir. J., January 1, 2004; 23(1): 93 - 97. [Abstract] [Full Text] [PDF]