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Eur Respir J 2002; 19:577-580
Copyright ©ERS Journals Ltd 2002

Statin-induced fibrotic nonspecific interstitial pneumonia

S. Lantuejoul1, E. Brambilla1, C. Brambilla2 and G. Devouassoux2

Depts of 1 Cellular Pathology and 2 Respiratory Medicine, Centre Hospitalier Universitaire de Grenoble, Université J.

CORRESPONDENCE: G. Devouassoux, Dept of Respiratory Diseases, Hôpital Albert Michallon, Centre Hospitalier Universitaire de Grenoble BP 217, 38043, Grenoble Cedex 09, France. Fax: 33 476765617. E-mail: GDevouassoux@chu-grenoble.fr

Keywords: hypersensitivity, nonspecific interstitial pneumonia, phospholipidosis, statins, toxic

Received: July 6, 2001
Accepted August 1, 2001

Abstract

Statins inhibit the 3-hydroxy-3-methylglutaryl coenzyme A reductase, reduce the serum level of low-density lipoprotein cholesterol, and are extensively prescribed to prevent cardiovascular mortality and morbidity. Few systemic adverse effects, such as pseudopolymyositis, lupus-like syndromes, and anecdotal hypersensitivity pneumonitis, have been reported.

A simvastatin-induced diffuse interstitial pneumonia associated with a nonspecific interstitial pneumonia pattern at histological analysis is repoted here. Ultrastructural analysis showed a diffuse cytoplasmic accumulation of intralysosomial lamellar inclusions in type II pneumonocytes, histiocytes and endothelial cells, suggesting a shared pathogenesis with amphiphilic drug-induced toxic lung injury. Because statins are increasingly prescribed, statin-induced interstitial lung disorders may be more frequently observed and early recognition will be required.




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