HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Lantuejoul, S. Articles by Devouassoux, G. Search for Related Content PubMed PubMed Citation Articles by Lantuejoul, S. Articles by Devouassoux, G.

Statin-induced fibrotic nonspecific interstitial pneumonia

Depts of ¹ Cellular Pathology and ² Respiratory Medicine, Centre Hospitalier Universitaire de Grenoble, Université J.

CORRESPONDENCE: G. Devouassoux, Dept of Respiratory Diseases, Hôpital Albert Michallon, Centre Hospitalier Universitaire de Grenoble BP 217, 38043, Grenoble Cedex 09, France. Fax: 33 476765617. E-mail: GDevouassoux@chu-grenoble.fr

Keywords: hypersensitivity, nonspecific interstitial pneumonia, phospholipidosis, statins, toxic

Received: July 6, 2001
Accepted August 1, 2001

Abstract

Statins inhibit the 3-hydroxy-3-methylglutaryl coenzyme A reductase, reduce the serum level of low-density lipoprotein cholesterol, and are extensively prescribed to prevent cardiovascular mortality and morbidity. Few systemic adverse effects, such as pseudopolymyositis, lupus-like syndromes, and anecdotal hypersensitivity pneumonitis, have been reported.

A simvastatin-induced diffuse interstitial pneumonia associated with a nonspecific interstitial pneumonia pattern at histological analysis is repoted here. Ultrastructural analysis showed a diffuse cytoplasmic accumulation of intralysosomial lamellar inclusions in type II pneumonocytes, histiocytes and endothelial cells, suggesting a shared pathogenesis with amphiphilic drug-induced toxic lung injury. Because statins are increasingly prescribed, statin-induced interstitial lung disorders may be more frequently observed and early recognition will be required.

This article has been cited by other articles:

				F. J. Martinez Idiopathic Interstitial Pneumonias: Usual Interstitial Pneumonia versus Nonspecific Interstitial Pneumonia. Proceedings of the ATS, January 1, 2006; 3(1): 81 - 95. [Abstract] [Full Text] [PDF]

				J-M. Naccache, M. Kambouchner, F. Girard, M. Antoine, A. Parrot, J. Piquet, M. Brauner, and D. Valeyre Relapse of respiratory insufficiency one year after organising pneumonia Eur. Respir. J., December 1, 2004; 24(6): 1062 - 1065. [Full Text] [PDF]