ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (45)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holt, P.G.
Right arrow Articles by Sly, P.D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holt, P.G.
Right arrow Articles by Sly, P.D.
Eur Respir J 2002; 19:538-545
Copyright ©ERS Journals Ltd 2002


Interactions between respiratory tract infections and atopy in the aetiology of asthma

P.G. Holt and P.D. Sly

TVW Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia

CORRESPONDENCE: P.G. Holt, Division of Cell Biology, TVW Telethon Institute for Child Health Research, P.O. Box 855, West Perth, WA 6872, Australia. Fax: 61 894897707. E-mail: patrick@ichr.uwa.edu.au

Keywords: asthma, atopy, bacterial stimuli, cytokines, viral infection

Received: March 22, 2001
Accepted May 8, 2001

Abstract

The prevalence of asthma, in particular atopic asthma, has markedly increased in recent years. Accumulating evidence suggests that environmental factors associated with allergic sensitization and exposure to microbial stimuli during infancy and early childhood, are associated with these changes in prevalence. However, considerable controversy surrounds the role of microbial agents, as evidence has been presented for both positive and negative effects in this context.

The review below focuses upon interactions between immune competence during infancy, the development of T-helper (Th)1-polarized versus Th2-polarized memory against inhalant allergens, and susceptibility to virus infection. In particular, recent finding are highlighted which suggest that delayed postnatal maturation of Th1 function is associated with increased risk for early postnatal sensitization to inhalant allergens, and also with risk for viral bronchiolitis during infancy.

Variations in the kinetics of postnatal maturation of T-helper 1 function may in part be attributable to polymorphisms in the CD14 gene, which influence host responsiveness both to bacterial as well as viral stimuli.




This article has been cited by other articles:


Home page
ThoraxHome page
B J Hales, L J Pearce, M M H Kusel, P G Holt, P D Sly, and W R Thomas
Differences in the antibody response to a mucosal bacterial antigen between allergic and non-allergic subjectsSmoke-free legislation reduces exposure in children
Thorax, March 1, 2008; 63(3): 221 - 227.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
L. Franchi, C. McDonald, T.-D. Kanneganti, A. Amer, and G. Nunez
Nucleotide-Binding Oligomerization Domain-Like Receptors: Intracellular Pattern Recognition Molecules for Pathogen Detection and Host Defense
J. Immunol., September 15, 2006; 177(6): 3507 - 3513.
[Abstract] [Full Text] [PDF]


Home page
Int ImmunolHome page
Y. Ishikawa, T. Yoshimoto, and K. Nakanishi
Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness
Int. Immunol., June 1, 2006; 18(6): 847 - 855.
[Abstract] [Full Text] [PDF]


Home page
ERRHome page
L. P. Nicod
INTRODUCTION
Eur. Respir. Rev., December 1, 2005; 14(95): 43 - 44.
[Full Text] [PDF]


Home page
ERRHome page
P. G. Holt
Developmental factors as determinants of risk for infections and atopy in childhood
Eur. Respir. Rev., December 1, 2005; 14(95): 69 - 73.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
H.-H. Shih, T.-M. Lin, J.-H. Chuang, H.-L. Eng, S.-H. H. Juo, F.-C. Huang, C.-L. Chen, and H.-L. Chen
Promoter Polymorphism of the CD14 Endotoxin Receptor Gene Is Associated With Biliary Atresia and Idiopathic Neonatal Cholestasis
Pediatrics, August 1, 2005; 116(2): 437 - 441.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
T. Hayashi, X. Gong, C. Rossetto, C. Shen, K. Takabayashi, V. Redecke, H. Spiegelberg, D. Broide, and E. Raz
Induction and Inhibition of the Th2 Phenotype Spread: Implications for Childhood Asthma
J. Immunol., May 1, 2005; 174(9): 5864 - 5873.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
N. Sigurs, P. M. Gustafsson, R. Bjarnason, F. Lundberg, S. Schmidt, F. Sigurbergsson, and B. Kjellman
Severe Respiratory Syncytial Virus Bronchiolitis in Infancy and Asthma and Allergy at Age 13
Am. J. Respir. Crit. Care Med., January 15, 2005; 171(2): 137 - 141.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Cell Mol. Bio.Home page
S. M. Stick and P. G. Holt
The Airway Epithelium as Immune Modulator: The LARC Ascending
Am. J. Respir. Cell Mol. Biol., June 1, 2003; 28(6): 641 - 644.
[Full Text] [PDF]


Home page
JEMHome page
P.G. Holt and P. D. Sly
Interactions between RSV Infection, Asthma, and Atopy: Unraveling the Complexities
J. Exp. Med., November 18, 2002; 196(10): 1271 - 1275.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the European Respiratory Society.