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1 Lung Pharmacology Group, Dept of Respiratory Medicine and Allergology, Göteborg University, Gothenburg and 2 Program for Respiratory Health and Climate, National Institute for Working Life, Solna, Sweden
CORRESPONDENCE: A. Lindén, Lung Pharmacology Group, Göteborg University, Guldhedsgatan 10A, S-413 46, Gothenburg, Sweden. Fax: 46 31413290. E-mail: anders.linden@lungall.gu.se
Keywords: cytokine, human airway, interleukin-17, neutrophil, organic dust, swine confinement
Received: September 17, 2001
Accepted November 23, 2001
The present study was funded by Göteborg University, the Swedish Heart Lung Foundation, the Swedish Medical Research Council (K2000-71X-09048-11A), the Vårdal Foundation and Glaxo Wellcome, Sweden.
Studies in rodents indicate that the cytokine, interleukin (IL)-17, links the activation of T-lymphocytes to neutrophilic inflammation. The aim of the current study was to determine whether free, soluble IL-17 protein can be released during severe inflammation in human airways.
Fifteen healthy subjects were exposed to a swine confinement in order to induce severe inflammation characterized by high neutrophil numbers in the airways. Bronchoalveolar lavage (BAL) fluid was harvested 2 weeks prior to and 24 h after this exposure and the concentration of IL-17 protein was measured using an enzyme-linked immunosorbent assay. Total and cell differential counts were also performed in BAL fluid.
Prior to exposure to the swine confinement, the concentration of IL-17 in BAL fluid was low (<7.8 pg·mL–1) in 14 out of 15 subjects. However, exposure to the swine confinement caused an increase in IL-17 in 13 out of 15 subjects (median IL-17 concentration of 26.9 pg·mL–1). This exposure also caused a 51-fold increase in the concentration of neutrophils in BAL fluid.
To conclude, free, soluble interleukin-17 protein can be released during severe inflammation characterized by high neutrophil numbers in human airways. The significance of interleukin-17 in inflammatory airway diseases therefore deserves further evaluation.
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