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1 Dept of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden. 2 Dept of Chest Diseases, Ain Shams University, Cairo, Egypt. 3 Depts of Pulmonary Medicine and Clinical Pharmacology, Sahlgrenska University Hospital, Gothenburg, Sweden
CORRESPONDENCE: E. Lindberg, Dept of Medical Sciences, Respiratory Medicine and Allergology, Akademiska Sjukhuset, S-751, 85, Uppsala, Sweden. Fax: 46 186112819. E-mail: eva.lindberg@medsci.uu.se
Keywords: catecholamines, hypertension, population-based, sleep apnoea
Received: December 22, 2000
Accepted October 26, 2001
This work was supported by the Swedish Heart and Lung Foundation.
Studies addressing the relationship between obstructive sleep apnoea (OSA) and sympathoadrenal activity have been criticized for poor control of factors known to confound sympathetic function, including hypertension. The aim of this study was to investigate the relationship between OSA and urinary catecholamines in a population-based sample of hypertensive males.
In 1994, 2,668 males aged 40–79 yrs answered a questionnaire regarding sleep disorders and somatic diseases. Of those who reported hypertension, an age-stratified sample of 116 was selected for monitoring of breathing during sleep and overnight urine analysis.
Subjects with OSA, defined as apnoea-hypopnoea index
The authors concluded that, in a population-based sample of hypertensive males, obstructive sleep apnoea is associated with increased urinary concentrations of extraneuronal metabolites of catecholamines independent of major confounding factors, suggesting increased sympathoadrenal activity. Elevated sympathoadrenal activity may explain the increased cardiovascular morbidity associated with obstructive sleep apnoea.
10·h–1, had higher concentrations of urinary normetanephrine (182±57 versus 141±45 µmol·mol–1 creatinine, p<0.001) and metanephrine (70±28 versus 61±28 µmol·mol–1 creatinine, p<0.05) in comparison to subjects without OSA. In a multiple regression analysis, there was an association between variables of sleep-disordered breathing and normetanephrine and metanephrine concentrations, independent of major confounding factors.
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