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Bronchial bacterial colonization in patients with resectable lung carcinoma

¹ Institutul National de Pneumoftiziologie "Marius Nasta" Bucharest, Romania, ² Sociedad Española de la Patologia del Aparato Respiratorio, ³ Unit of Respiratory Intensive Care, Dept of Pulmonology, Clinical Institute of Pulmonology and Thoracic Surgery, Hospital Clinic, Institute of Biomedical Investigation August Pi i Sunyer (IDIBAPS), University of Barcelona, Spain. ⁴ Abteilung für Pneumologie, Allergologie und Schlafmedizin, Medizinische Klinik und PolikIink Bergmannsheil, Klinikum der Ruhr-Universität, Bochum, Germany

CORRESPONDENCE: A. Torres, Servei de Pneumologia, Institut Clinic de Pneumologia i Cirurgia Toracica, Hospital Clinic i Provincial, Villarroel, 170, 08036, Barcelona, Spain. Fax: 34 932275454

Keywords: colonization, lung carcinoma, risk factors

Received: February 28, 2001
Accepted October 16, 2001

This study was supported by a fellowship of the European Respiratory Society and a grant from the Generalitat of Catalunya (1999SGR00228).

The pattern and clinical implications of bronchial bacterial colonization have been widely investigated in patients with chronic lung disease, particularly chronic obstructive pulmonary disease. The main aim of this study was to determine the frequency and risk factors for bronchial colonization in lung cancer patients who have undergone surgical resection.

Forty-one patients with resectable lung cancer (22 (54%) active smokers, 52±23 pack-yrs) with a mean forced expiratory volume in one second of 80±16% predicted, were studied with bilateral protected specimen brush and lung tissue biopsy during the surgical procedure. Quantitative bacterial culture, susceptibility tests and histological examination of samples were performed.

Bronchial colonization with 1 potential pathogenic micro-organism was found in 17 of 41 (41%) patients. The most frequent strains isolated were: Haemophilus influenzae (35%), Streptococcus pneumoniae (13%) and Pseudomonas spp. (9%). The risk factors for bronchial colonization were central location of the tumour (odds ratio (OR)=9.2, confidence interval (CI) 95%=2.1–39.6, p=0.003) and increased body mass index (OR=1.6, CI 95%=1.2–2.2, p=0.005). The frequency of postoperative infectious pulmonary complications was low (five cases (12%)) and no relationship was observed with bronchial colonization.

Patients with resectable lung carcinoma had a high rate of bronchial colonization (41%), mainly with potential pathogenic microorganisms. The independent risk factors for colonization in these patients were central location of the tumour and a high body mass index.

This article has been cited by other articles:

				J. Belda, M. Cavalcanti, M. Ferrer, M. Serra, J. Puig de la Bellacasa, E. Canalis, and A. Torres Bronchial Colonization and Postoperative Respiratory Infections in Patients Undergoing Lung Cancer Surgery Chest, September 1, 2005; 128(3): 1571 - 1579. [Abstract] [Full Text] [PDF]

				A. Rosell, E. Monso, N. Soler, F. Torres, J. Angrill, G. Riise, R. Zalacain, J. Morera, and A. Torres Microbiologic Determinants of Exacerbation in Chronic Obstructive Pulmonary Disease Arch Intern Med, April 25, 2005; 165(8): 891 - 897. [Abstract] [Full Text] [PDF]