HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Gaede, K.I. Articles by Müller-Quernheim, J. Search for Related Content PubMed PubMed Citation Articles by Gaede, K.I. Articles by Müller-Quernheim, J.

Anti-Chlamydophila immunoglobulin prevalence in sarcoidosis and usual interstitial pneumoniae

¹ Medical Hospital and ² Dept of Immunochemistry and Biochemical Microbiology, Research Centre Borstel, Borstel, Germany

CORRESPONDENCE: K.I. Gaede, Research Centre Borstel, Medical Hospital, Parkallee 35, D-23845, Borstel, Germany. Fax: 49 4537188313. E-mail: kgaede@fz-borstel.de

Keywords: bronchoalveolar lavage fluid, chlamydophila, sarcoidosis, serum, usual interstitial pneumoniae

Received: February 9, 2001
Accepted September 30, 2001

Sarcoidosis and usual interstitial pneumoniae (UIP) are diseases of unknown aetiology affecting the lower respiratory tract. Although there are a number of studies investigating the causal role of these disorders, no micro-organism could be identified as the causal agent. The high incidence of Chlamydophila pneumoniae infections associated with lung injury encouraged the present investigations to screen patients with sarcoidosis and with UIP for their Chlamydophila-specific immune response.

Thirty-nine patients with sarcoidosis, 26 patients with UIP and 34 controls were tested for the prevalence of Chlamydophila-specific antibodies in bronchoalveolar lavage fluids (BALF) and sera. Samples were tested for the presence of antibodies in a genus-specific test for Chlamydophila-lipopolysaccharide (LPS) and in a species-specific test for C. pneumoniae.

This study revealed a significantly higher prevalence of Chlamydophila LPS-specific immunoglobulin (Ig)-G in the BALF of sarcoidosis patients (36.8%) compared to controls (8.8%) and patients with UIP (12.0%). Similar findings were observed in sera. The prevalence of C. pneumoniae-specific antibodies in BALF was significantly higher in sarcoidosis patients for IgG and IgA (IgG: 74.4%; IgA: 46.2%) and in UIP for IgG (IgG: 50.0%; IgA: 11.5%) compared to controls (IgG: 14.7%; IgA: 14.7%).

The elevated prevalence of Chlamydophila-specific antibodies in sarcoidosis patients might implicate Chlamydophila as a causal agent. However, considering the high prevalence of Chlamydophila antibodies in the healthy population, the data presented might reflect Chlamydophila co-infections in pre-injured lungs seen in these patients.

This article has been cited by other articles:

				C. S. Little, A. Bowe, R. Lin, J. Litsky, R. M. Fogel, B. J. Balin, and K. L. Fresa-Dillon Age Alterations in Extent and Severity of Experimental Intranasal Infection with Chlamydophila pneumoniae in BALB/c Mice Infect. Immun., March 1, 2005; 73(3): 1723 - 1734. [Abstract] [Full Text] [PDF]

				M. A. Judson The Etiologic Agent of Sarcoidosis: What If There Isn't One? Chest, July 1, 2003; 124(1): 6 - 8. [Full Text] [PDF]