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Eur Respir J 2002; 19:54-60
Copyright ©ERS Journals Ltd 2002

Improved quality of life after lung volume reduction surgery

J. Hamacher1, S. Büchi3, C.L. Georgescu1, U. Stammberger2, R. Thurnheer1, K.E. Bloch1, W. Weder2 and E.W. Russi1

1 Pulmonary Division, Dept of Internal Medicine, 2 Division of Thoracic Surgery, Dept of Surgery, 3 Division of Psychosocial Medicine, Dept of Psychiatry, University Hospital, Zürich, Switzerland

CORRESPONDENCE: E.W. Russi, Pulmonary Division, Dept of Internal Medicine, University Hospital, CH- 8091, Zürich, Switzerland. Fax: 41 12554451

Keywords: Emphysema, lung volume reduction surgery, quality of life

Received: August 24, 2001
Accepted September 2, 2001

This study was supported by grant no. 3200-043358; 95.1 from the Swiss National Science Fund and by a grant from the Zürich Lung League.

Lung volume reduction surgery (LVRS) improves dyspnoea, pulmonary function, and physical performance in patients with severe pulmonary emphysema. This study investigated the impact of LVRS on health-related quality of life (HRQL) over a 2-yr period following surgery.

Thirty-nine consecutive patients were prospectively assessed before LVRS, and followed over 24 months postoperatively. The assessments included pulmonary function, dyspnoea (Medical Research Council (MRC) dyspnoea score), 6-min walking distance (6MWD) and HRQL using the Short Form 36-item questionnaire (SF-36) .

Several domains of SF-36 improved considerably over 2 yrs after surgery: Physical Functioning: 39±4 (mean±sem) versus 16±2 (p<0.01); Vitality: 51±3 versus 32±3 (p<0.01); Social Functioning: 72±4 versus 51±5 (p<0.01). Also, improvements in pulmonary function (forced expiratory volume in one second (FEV1): 27±1% predicted, residual volume (RV)/total lung capacity (TLC): 0.65±0.01), 6 MWD (274±16 m) and dyspnoea (MRC: 3.9±01) were sustained for up to 2 yrs after LVRS (FEV1 36±2% pred, RV/TLC: 0.58±0.02; 6 MWD: 342±19 m; MRC: 2.0±0.2; p<0.05).

In patients with severe emphysema, lung volume reduction surgery had positive effects on health-related quality of life and pulmonary function over 2 yrs.




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