|
|
||||||||
1 Dept of Pathology, Ruhr-University Bochum, Bochum and 2 Institute of Medical Microbiology and Hygiene, Medical University of Lübeck, Lübeck, Germany
CORRESPONDENCE: D. Theegarten, Dept of Pathology, Ruhr-University Bochum, Universitaetsstr. 150 , D-44801, Bochum, Germany. Fax: 49 2343214200
Keywords: Bronchiolitis, Chlamydia pneumoniae, pathogenesis, primary pulmonary hypertension, smooth muscle cells
Received: May 21, 2001
Accepted July 5, 2001
Abstract
The pathogenesis of primary pulmonary hypertension is still unclear. The case of a 68-yr-old female patient who complained of recurrent dizzy spells and collapses over a period of 6 weeks and died of global cardiac failure is presented.
Autopsy revealed severe pulmonary hypertension, slight chronic bronchitis, and bronchiolitis as well as intra-alveolar accumulation of macrophages. Chlamydiae were detected within the pulmonary arteries and in intramural and intra-alveolar macrophages by immunofluorescence, confocal laser scanning microscopy, scanning and transmission electron microscopy. Nested-polymerase chain reaction (PCR) and nonradioactive deoxyribonucleic acid (DNA) hybridization of PCR products from pulmonary arteries revealed Chlamydia pneumoniae DNA.
Chlamydia pneumoniae has already been detected in atherosclerosis and in pulmonary emphysema. It can induce proliferation of smooth muscle cells. Chlamydia pneumoniae might be relevant in aggravation of primary pulmonary hypertension and might perhaps be a trigger factor in some cases.
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |