| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 The Immunopharmacological Research Group, Medical School, University of Tampere, Depts of 2 Clinical Chemistry, 3 Respiratory Medicine and 4 Clinical Physiology, Tampere University Hospital
CORRESPONDENCE: E. Moilanen, Medical School, University of Tampere, Tampere, FIN-;33014, Finland. Fax: 358 32158082
Keywords: asthma, eosinophil cationic protein, eosinophil protein X, exhaled nitric oxide, inflammation, inhaled glucocorticoids
Received: January 18, 2001
Accepted June 12, 2001
The present study was supported by grants from the National Technology Agency (Tekes), Tampere University Hospital Medical Research Fund, Tampere Tuberculosis Foundation and the Academy of Finland.
Exhaled nitric oxide (NO) concentration is a noninvasive measure of airway inflammation and is increased in asthma. Inhaled glucocorticoids decrease exhaled NO concentration, but the relative contributions of alveolar and bronchial levels to the decrease in exhaled NO concentration are unknown. Alveolar NO concentration and bronchial NO flux can be separately approximated by measuring exhaled NO at several exhalation flow rates. The effect of steroid treatment on alveolar and bronchial NO output in asthma was studied.
Alveolar NO concentration and bronchial NO flux were assessed in 16 patients with asthma before and during treatment with inhaled fluticasone for 8 weeks and in 16 healthy controls.
Before the treatment, asthmatics had increased bronchial NO flux (mean±sem: 3.6±0.4 versus 0.7±0.1 nL·s–1, p<0.001) but normal alveolar NO concentration (1.2±0.5 versus 1.0±0.2 parts per billion (ppb), p>0.05) compared with controls. Inhaled fluticasone decreased bronchial NO flux from 3.6±0.4 to 0.7±0.1 nL·s–1 (p<0.01) but had no effect on alveolar NO concentration (before: 1.2±0.5; after: 1.2±0.1 ppb, p>0.05). The forced expiratory volume in one second improved, whereas asthma symptom score and serum levels of eosinophil cationic protein and eosinophil protein X decreased during the treatment.
In conclusion, inhaled fluticasone decreases bronchial but not alveolar nitric oxide output simultaneously with clinical improvement in patients with asthma.
This article has been cited by other articles:
|
|
 |
|
  H. Lehtonen, P. Oksa, L. Lehtimaki, A. Sepponen, R. Nieminen, H. Kankaanranta, S. Saarelainen, R. Jarvenpaa, J. Uitti, and E. Moilanen Increased alveolar nitric oxide concentration and high levels of leukotriene B4 and 8-isoprostane in exhaled breath condensate in patients with asbestosis Thorax, July 1, 2007; 62(7): 602 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Brindicci, K. Ito, P. J. Barnes, and S. A. Kharitonov Differential Flow Analysis of Exhaled Nitric Oxide in Patients With Asthma of Differing Severity Chest, May 1, 2007; 131(5): 1353 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Roy, Z. L. Borrill, C. Starkey, A. L. Hazel, J. Morris, J. Vestbo, and D. Singh Use of different exhaled nitric oxide multiple flow rate models in COPD Eur. Respir. J., April 1, 2007; 29(4): 651 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-W. Shin, D. A. Shelley, E. M. Henderson, A. Fitzpatrick, B. Gaston, and S. C. George Airway nitric oxide release is reduced after PBS inhalation in asthma J Appl Physiol, March 1, 2007; 102(3): 1028 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Paraskakis, C. Brindicci, L. Fleming, R. Krol, S. A. Kharitonov, N. M. Wilson, P. J. Barnes, and A. Bush Measurement of Bronchial and Alveolar Nitric Oxide Production in Normal Children and Children with Asthma Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 260 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Gelb, C. Flynn Taylor, C. M. Shinar, C. Gutierrez, and N. Zamel Role of Spirometry and Exhaled Nitric Oxide To Predict Exacerbations in Treated Asthmatics Chest, June 1, 2006; 129(6): 1492 - 1499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 ATS Workshop Proceedings: Exhaled Nitric Oxide and Nitric Oxide Oxidative Metabolism in Exhaled Breath Condensate. Proceedings of the ATS, January 1, 2006; 3(2): 131 - 145. [Full Text] [PDF]
|
|
|
|
|
|
C. Brindicci, K. Ito, O. Resta, N. B. Pride, P. J. Barnes, and S. A. Kharitonov Exhaled nitric oxide from lung periphery is increased in COPD Eur. Respir. J., July 1, 2005; 26(1): 52 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Berry, B. Hargadon, A. Morgan, M. Shelley, J. Richter, D. Shaw, R. H. Green, C. Brightling, A. J. Wardlaw, and I. D. Pavord Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma Eur. Respir. J., June 1, 2005; 25(6): 986 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005 Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 912 - 930. [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kharitonov and P. J. Barnes Effects of Corticosteroids on Noninvasive Biomarkers of Inflammation in Asthma and Chronic Obstructive Pulmonary Disease Proceedings of the ATS, November 1, 2004; 1(3): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Gelb, C. F. Taylor, E. Nussbaum, C. Gutierrez, A. Schein, C. M. Shinar, M. J. Schein, J. D. Epstein, and N. Zamel Alveolar and Airway Sites of Nitric Oxide Inflammation in Treated Asthma Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 737 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-W. Shin, P. Condorelli, C. M. Rose-Gottron, D. M. Cooper, and S. C. George Probing the impact of axial diffusion on nitric oxide exchange dynamics with heliox J Appl Physiol, September 1, 2004; 97(3): 874 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. George, M. Hogman, S. Permutt, and P. E. Silkoff Modeling pulmonary nitric oxide exchange J Appl Physiol, March 1, 2004; 96(3): 831 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-W. Shin, C. M. Rose-Gottron, D. M. Cooper, R. L. Newcomb, and S. C. George Airway diffusing capacity of nitric oxide and steroid therapy in asthma J Appl Physiol, January 1, 2004; 96(1): 65 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Tornberg, H. Bjorne, J. O. Lundberg, and E. Weitzberg Multiple Single-breath Measurements of Nitric Oxide in the Intubated Patient Am. J. Respir. Crit. Care Med., November 15, 2003; 168(10): 1210 - 1215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lehtimaki, H. Kankaanranta, S. Saarelainen, V. Turjanmaa, and E. Moilanen Increased alveolar nitric oxide concentration in asthmatic patients with nocturnal symptoms Eur. Respir. J., October 1, 2002; 20(4): 841 - 845. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
