| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology (ICP), University of Louvain, Brussels, Belgium
CORRESPONDENCE: Y. Sibille, Unité de Médecine expérimentale, 74 avenue Hippocrate BP 7430, 1200, Bruxelles, Belgique. Fax: 32 81423352
Keywords: Fc
R, immunoglobulin-A, mucosal immunity, polymeric immunoglobulin receptor
Received: March 22, 2001
Accepted May 8, 2001
C. Pilette is currently Aspirant of the Fonds National de la Recherche Scientifique (Belgium) and Y. Ouadrhiri is supported by the Fondation Lancardis (Switzerland).
Abstract
Mucosal defence mechanisms are critical in preventing colonization of the respiratory tract by pathogens and penetration of antigens through the epithelial barrier. Recent research has now illustrated the active contribution of the respiratory epithelium to the exclusion of microbes and particles, but also to the control of the inflammatory and immune responses in the airways and in the alveoli. Epithelial cells also mediate the active transport of polymeric immunoglobulin-A from the lamina propria to the airway lumen through the polymeric immunoglobulin receptor. The role of IgA in the defence of mucosal surfaces has now expanded from a limited role of scavenger of exogenous material to a broader protective function with potential applications in immunotherapy. In addition, the recent identification of receptors for IgA on the surface of blood leukocytes and alveolar macrophages provides an additional mechanism of interaction between the cellular and humoral immune systems at the level of the respiratory tract.
This article has been cited by other articles:
|
|
 |
|
  M. M. Kahl-McDonagh, A. M. Arenas-Gamboa, and T. A. Ficht Aerosol Infection of BALB/c Mice with Brucella melitensis and Brucella abortus and Protective Efficacy against Aerosol Challenge Infect. Immun., October 1, 2007; 75(10): 4923 - 4932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Baron, R. Singh, and D. W. Metzger Inactivated Francisella tularensis Live Vaccine Strain Protects against Respiratory Tularemia by Intranasal Vaccination in an Immunoglobulin A-Dependent Fashion Infect. Immun., May 1, 2007; 75(5): 2152 - 2162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Twigg III Humoral Immune Defense (Antibodies): Recent Advances Proceedings of the ATS, December 1, 2005; 2(5): 417 - 421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gupta, M. Heacock, A. Perez, and P. B. Davis Antibodies to the Polymeric Immunoglobulin Receptor with Different Binding and Trafficking Patterns Am. J. Respir. Cell Mol. Biol., October 1, 2005; 33(4): 363 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barnes Mediators of Chronic Obstructive Pulmonary Disease Pharmacol. Rev., December 1, 2004; 56(4): 515 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Arnold, D. Bumann, M. Felies, B. Gewecke, M. Sorensen, J. E. Gessner, J. Freihorst, B. U. von Specht, and U. Baumann Enhanced Immunogenicity in the Murine Airway Mucosa with an Attenuated Salmonella Live Vaccine Expressing OprF-OprI from Pseudomonas aeruginosa Infect. Immun., November 1, 2004; 72(11): 6546 - 6553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sun, F.-E. Johansen, L. Eckmann, and D. W. Metzger An Important Role for Polymeric Ig Receptor-Mediated Transport of IgA in Protection against Streptococcus pneumoniae Nasopharyngeal Carriage J. Immunol., October 1, 2004; 173(7): 4576 - 4581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pilette, S. R. Durham, J.-P. Vaerman, and Y. Sibille Mucosal Immunity in Asthma and Chronic Obstructive Pulmonary Disease: A Role for Immunoglobulin A? Proceedings of the ATS, April 1, 2004; 1(2): 125 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.J. Barnes, S.D. Shapiro, and R.A. Pauwels Chronic obstructive pulmonary disease: molecular and cellularmechanisms Eur. Respir. J., October 1, 2003; 22(4): 672 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. TUMA and A. L. HUBBARD Transcytosis: Crossing Cellular Barriers Physiol Rev, July 1, 2003; 83(3): 871 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pilette, Y. Ouadrhiri, F. Dimanche, J.-P. Vaerman, and Y. Sibille Secretory Component Is Cleaved by Neutrophil Serine Proteinases but its Epithelial Production Is Increased by Neutrophils through NF-{kappa}B- and p38 Mitogen-Activated Protein Kinase-Dependent Mechanisms Am. J. Respir. Cell Mol. Biol., April 1, 2003; 28(4): 485 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sohy, C. Pilette, M.S. Niederman, and Y. Sibille Acute exacerbation of chronic obstructive pulmonary disease and antibiotics: what studies are still needed? Eur. Respir. J., May 1, 2002; 19(5): 966 - 975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lusuardi, A. Capelli, A. Di Stefano, and C.F. Donner Lung mucosal immunity: immunoglobulin-A revisited Eur. Respir. J., April 1, 2002; 19(4): 785 - 786. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
