| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Dept of Physiology, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin, Ireland
CORRESPONDENCE: A. Bradford, Dept of Physiology, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland. Fax: 353 014022447
Keywords: haematocrit, hypercapnia, hypoxia, pulmonary arterial pressure, sleep apnoea
Received: September 9, 2000
Accepted March 26, 2001
Sleep-disordered breathing is associated with pulmonary hypertension and raised haematocrit. The multiple episodes of apnoea in this condition cause chronic intermittent hypoxia and hypercapnia but the effects of such blood gas changes on pulmonary pressure or haematocrit are unknown. The present investigation tests the hypothesis that chronic intermittent hypercapnic hypoxia causes increased pulmonary arterial pressure and erythropoiesis.
Rats were treated with alternating periods of normoxia and hypercapnic hypoxia every 30 s for 8 h per day for 5 days per week for 5 weeks, as a model of the intermittent blood gas changes which occur in sleep-disordered breathing in humans. Haematocrit, red blood cell count and haemoglobin concentration were measured each week and systemic and pulmonary arterial blood pressure and heart weight were measured after 5 weeks.
In relation to control, chronic intermittent hypercapnic hypoxia caused a significant increase in systemic (104.3±4.7 mmHg versus 121.0±10.4 mmHg) and pulmonary arterial pressure (20.7±6.8 mmHg versus 31.3±7.2 mmHg), right ventricular weight (expressed as ratios) and haematocrit (45.2±1.0% versus 51.5±1.5%).
It is concluded that the pulmonary hypertension and elevated haematocrit associated with sleep-disordered breathing is caused by chronic intermittent hypercapnic hypoxia.
This article has been cited by other articles:
|
|
 |
|
  P. Levy, J-L. Pepin, C. Arnaud, R. Tamisier, J-C. Borel, M. Dematteis, D. Godin-Ribuot, and C. Ribuot Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives Eur. Respir. J., October 1, 2008; 32(4): 1082 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. V. Serebrovskaya, E. B. Manukhina, M. L. Smith, H. F. Downey, and R. T. Mallet Intermittent Hypoxia: Cause of or Therapy for Systemic Hypertension? Experimental Biology and Medicine, June 1, 2008; 233(6): 627 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. de Frutos, L. Duling, D. Alo, T. Berry, O. Jackson-Weaver, M. Walker, N. Kanagy, and L. Gonzalez Bosc NFATc3 is required for intermittent hypoxia-induced hypertension Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2382 - H2390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen, J. Zhang, T. X. Gan, Y. Chen-Izu, J. D. Hasday, M. Karmazyn, C. W. Balke, and S. M. Scharf Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia J Appl Physiol, January 1, 2008; 104(1): 218 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Bavis, F. L. Powell, A. Bradford, C. C.W. Hsia, J. E. Peltonen, J. Soliz, B. Zeis, E. K. Fergusson, Z. Fu, M. Gassmann, et al. Respiratory plasticity in response to changes in oxygen supply and demand Integr. Comp. Biol., October 1, 2007; 47(4): 532 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Olkowski Pathophysiology of Heart Failure in Broiler Chickens: Structural, Biochemical, and Molecular Characteristics Poult. Sci., May 1, 2007; 86(5): 999 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Campen, L. A. Shimoda, and C. P. O'Donnell Acute and chronic cardiovascular effects of intermittent hypoxia in C57BL/6J mice J Appl Physiol, November 1, 2005; 99(5): 2028 - 2035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dunleavy, M. Dooley, D. Cox, and A. Bradford Chronic intermittent asphyxia increases platelet reactivity in rats Exp Physiol, May 1, 2005; 90(3): 411 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zielinski Effects of intermittent hypoxia on pulmonary haemodynamics: animal models versus studies in humans Eur. Respir. J., January 1, 2005; 25(1): 173 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bradford Festschrift for R. G. O'Regan - Sensing and adaptation to alterations in respiratory gases: oxygen and carbon dioxide: Effects of chronic intermittent asphyxia on haematocrit, pulmonary arterial pressure and skeletal muscle structure in rats Exp Physiol, January 1, 2004; 89(1): 44 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Zabka, G. S. Mitchell, E. B. Olson Jr, and M. Behan Selected Contribution: Chronic intermittent hypoxia enhances respiratory long-term facilitation in geriatric female rats J Appl Physiol, December 1, 2003; 95(6): 2614 - 2623. [Abstract] [Full Text]
|
|
|
|
|
|
M. McGuire, Y. Zhang, D. P. White, and L. Ling Chronic intermittent hypoxia enhances ventilatory long-term facilitation in awake rats J Appl Physiol, October 1, 2003; 95(4): 1499 - 1508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. McGuire, M. MacDermott, and A. Bradford The Effects of Chronic Episodic Hypercapnic Hypoxia on Rat Upper Airway Muscle Contractile Properties and Fiber-Type Distribution Chest, October 1, 2002; 122(4): 1400 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Weitzenblum and A. Chaouat Hypoxic pulmonary hypertension in man: what minimum daily duration of hypoxaemia is required? Eur. Respir. J., August 1, 2001; 18(2): 251 - 253. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
