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Monitoring of nonlinear respiratory elastance using a multiple linear regression analysis

¹ Dept of Pediatrics, Fukuoka Tokushukai Medical Center, Kasuga City, ² Dept of Pediatrics, Fukuoka University, Nanakuma, Jonan-ku, Fukuoka, Japan

CORRESPONDENCE: K. Muramatsu, Dept of Pediatrics, Fukuoka Tokushukai Medical Center, 4-5 Suku-kita, Kasuga City, Fukuoka, 816-0864, Japan. Fax: 81 925731733

Keywords: elastance curve, multiple regression analysis, pressure/volume curve, respiratory mechanics, respiratory physiology

Received: February 28, 2000
Accepted December 12, 2000

The elastic pressure/volume (P/V) curve obtained by the multiple linear regression (MLR) technique using a new model, was compared with the quasi-static P/V points obtained by the rapid airway occlusion technique.

Seven infants were studied during mechanical ventilation using a pressure controlled mode. The resistive pressure was subtracted from airway opening pressure, thus determining the elastance related pressure, which was then plotted against the volume to make an MLR-elastance curve. Quasi-static P/V curves of the rapid occlusion technique were constructed by plotting the different inspiratory and expiratory volumes against the corresponding values of the quasi-static airway pressure.

The calculated MLR-elastance curves closely fit the experimental quasi-static P/V points obtained by the occlusion technique. There were, however, some discrepancies due to the viscoelastic behaviour of the respiratory system.

Although slightly altered by these discrepancies, the multiple linear regression-elastance curves did fit the observed quasi-static pressure/volume characteristics for use in clinical practice. The multiple linear regression technique may prove to be clinically useful by continuous monitoring of respiratory system mechanics during mechanical ventilation.