Copyright ©ERS Journals Ltd 2001 Endothelin-1-induced airway and parenchymal mechanical responses in guinea-pigs: the roles of ETA and ETB receptors1 Institute of Surgical Research, 2 Dept of Medical Informatics and Engineering and 3 Dept of Pathology, University of Szeged, Szeged, Hungary CORRESPONDENCE: Z. Hantos, Dept of Medical Informatics and Engineering University of Szeged, H-6701, Szeged, P.O. Box 427, Hungary. Fax: 36 62544566 Keywords: airway resistance, endothelin-1, endothelin receptor antagonists, lung elastance, lung impedance, parenchymal resistance
Received: March 16, 2000
This study was supported by Hungarian Scientific Research Fund grants T30670 and T023089.
Endothelin-1 (ET-1) has been shown to have a constrictor effect on the airways and parenchyma; however, the roles of the ETA and ETB receptors in the ET-1-induced changes in the airway and tissue compartments have not been fully explored.
Low-frequency pulmonary impedance (ZL) was measured in anaesthetized, paralysed, open-chest guinea-pigs. ZL spectra were fitted by a model to estimate airway resistance (Raw) and inertance (Iaw), and coefficients of tissue damping (G) and elastance (H), and hysteresivity (
Two successive doses of ET-1 (0.05 and 0.2 nmol·kg1) each evoked significant dose-related increases in Raw, G, H and
The results of the separate assessments of the airway and tissue mechanics demonstrate that endothelin-1 induces airway and parenchymal constriction via stimulation of both receptor types in both compartments.
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