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1 Dept of Pneumology, Respiratory and Environmental Research Unit, Hospital del Mar-IMIM, CEXS, Pompeu Fabra University and Autonomous University of Barcelona and 2 Dept of Physiology, School of Sciences, University of Barcelona, Barcelona, Spain
CORRESPONDENCE: J.G. Gea, Unitat de Recerca Respiratòria I Ambiental, IMIM-Hospital del Mar, E-8003, Barcelona, Spain. Fax: 34 932213237
Keywords: citrate synthase, creatinine kinase, lactate dehydrogenase, lung diseases, peripheral skeletal muscle function, phosphofructokinase
Received: July 5, 2000
Accepted December 12, 2000
The purpose of this study was to analyse key enzyme activities of the deltoid muscle (DM) in chronic obstructive pulmonary disease (COPD) patients.
The activities of one oxidative enzyme (citrate synthase (CS)), two glycolytic enzymes (lacatate dehydrogenase (LD); and phosphofructokinase (PFK)) and one enzyme related to the use of energy stores (creatine kinase (CK)) were determined in the DM of 10 patients with COPD and nine controls. Exercise capacity (cycloergometry) and the handgrip strength were also evaluated.
Although exercise capacity was markedly reduced in COPD (57±20% predicted), their handgrip strength was relatively preserved (77±19% pred). The activity of LD was higher in the COPD patients (263.9±68.2 versus 184.4±46.5 mmol·min–1·g–1, p<0.01), with a similar trend for CS (67.3±33.3 versus 46.0±17.4 mmol·min–1·g–1, p=0.07). Interestingly, the activity of the latter enzyme was significantly higher than controls if only severe COPD patients were considered (81.8±31.2 mmol·min–1·g–1, p<0.01). PFK and CK activities were similar for controls and COPD.
Chronic obstructive patients show a preserved or even increased (severe disease) oxidative capacity in their deltoid muscle. This coexists with a greater capacity in the anaerobic part of the glycolysis. These findings are different to those previously observed in muscles of the lower limbs.
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