| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Dept of Pneumology, Vall d'Hebron General University Hospital, Barcelona, Spain and 2 Pharma Research, Division of Pharma Consult Services S.A., Barcelona, Spain
CORRESPONDENCE: M. Miravitlles, Rocafort 173-177, 08015, Barcelona, Spain. Fax: 34 932746083
Keywords: chronic bronchitis, comorbidity, exacerbation, failure, primary care, treatment
Received: July 26, 2000
Accepted December 1, 2000
The DAFNE Group is funded by MERCK Farma y Química S.A.
This study aimed to identify the risk factors for relapse after ambulatory treatment of acute exacerbations of chronic bronchitis (AECB) that can easily be used in a primary care setting.
Data were prospectively collected on 2,414 ambulatory patients with AECB from 268 general practices located throughout Spain. A multivariate model to identify risk factors independently associated with failures was developed and validated from the information recorded at the inclusion visit and at 30-days follow-up visit.
A total of 507 patients relapsed (21%); of these, 84 required admission (16.5%). The multivariate model for prediction of the risk of relapse included 2,414 cases: 1,689 for the developmental sample and 725 in the validation sample. The model obtained contained three readily-obtainable variables: ischaemic heart disease (odds ratio (OR)=1.63; 95% confidence interval (CI)=1.07–2.47), degree of dyspnoea (OR=1.31; 1.14–1.50) and number of visits to the general practitioner the previous year (OR=1.07; 1.04–1.10). The model calibrated well in developmental and validation samples (goodness-of-fit tests: p=0.295 and p=0.637, respectively). Severity of the exacerbation was not associated with increased risk of relapse in either univariate or multivariate analysis.
The present results suggest that baseline characteristics of the patients such as degree of dyspnoea, coexisting ischaemic heart disease and number of previous visits to the general practitioner for respiratory problems are strongly associated with increased risk of relapse after ambulatory treatment of acute exacerbations of chronic bronchitis. In contrast, exacerbation severity was not associated with clinical failure. Guidelines for management of acute exacerbations of chronic bronchitis should consider such risk factors and advocate intensive broad spectrum treatment and closer follow-up of patients exhibiting them.
This article has been cited by other articles:
|
|
 |
|
  M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al. Outcomes for COPD pharmacological trials: from lung function to biomarkers Eur. Respir. J., February 1, 2008; 31(2): 416 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miravitlles Review: Do we need new antibiotics for treating exacerbations of COPD? Therapeutic Advances in Respiratory Disease, October 1, 2007; 1(1): 61 - 76. [Abstract] [PDF]
|
|
|
|
 |
|
 British Thoracic Society Guideline Development Gro Intermediate care--Hospital-at-Home in chronic obstructive pulmonary disease: British Thoracic Society guideline Thorax, March 1, 2007; 62(3): 200 - 210. [Full Text] [PDF]
|
|
|
|
|
|
S Scott, P Walker, and P M A Calverley COPD exacerbations {middle dot} 4: Prevention Thorax, May 1, 2006; 61(5): 440 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Wilson, P Jones, T Schaberg, P Arvis, I Duprat-Lomon, P P Sagnier, and for the MOSAIC Study Group Antibiotic treatment and factors influencing short and long term outcomes of acute exacerbations of chronic bronchitis Thorax, April 1, 2006; 61(4): 337 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Martinez, R. F. Grossman, N. Zadeikis, A. C. Fisher, K. Walker, M. E. Ambruzs, and A. M. Tennenberg Patient stratification in the management of acute bacterial exacerbation of chronic bronchitis: the role of levofloxacin 750 mg Eur. Respir. J., June 1, 2005; 25(6): 1001 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Miravitlles, M Ferrer, A Pont, R Zalacain, J L Alvarez-Sala, F Masa, H Verea, C Murio, F Ros, and R Vidal Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study Thorax, May 1, 2004; 59(5): 387 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miravitlles and A. Torres No More Equivalence Trials for Antibiotics in Exacerbations of COPD, Please Chest, March 1, 2004; 125(3): 811 - 813. [Full Text] [PDF]
|
|
|
|
|
|
R. Wilson, L. Allegra, G. Huchon, J.-L. Izquierdo, P. Jones, T. Schaberg, and P.-P. Sagnier Short-term and Long-term Outcomes of Moxifloxacin Compared to Standard Antibiotic Treatment in Acute Exacerbations of Chronic Bronchitis Chest, March 1, 2004; 125(3): 953 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kim, C. L. Emerman, R. K. Cydulka, B. H. Rowe, S. Clark, and C. A. Camargo Prospective Multicenter Study of Relapse Following Emergency Department Treatment of COPD Exacerbation Chest, February 1, 2004; 125(2): 473 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miravitlles, C. Murio, T. Guerrero, and R. Gisbert Costs of Chronic Bronchitis and COPD: A 1-Year Follow-up Study Chest, March 1, 2003; 123(3): 784 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.W. Jones, L.R. Willits, P.S. Burge, and P.M.A. Calverley Disease severity and the effect of fluticasone propionate on chronic obstructive pulmonary disease exacerbations Eur. Respir. J., January 1, 2003; 21(1): 68 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miravitlles Exacerbations of chronic obstructive pulmonary disease: when are bacteria important? Eur. Respir. J., July 1, 2002; 20(36_suppl): 9S - 19s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miravitlles, C. Murio, T. Guerrero, and R. Gisbert Pharmacoeconomic Evaluation of Acute Exacerbations of Chronic Bronchitis and COPD* Chest, May 1, 2002; 121(5): 1449 - 1455. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
