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Comparison of the acute effects of salbutamol and terbutaline on heart rate variability in adult asthmatic patients

Depts of ¹ Cardiology and ² Chest Diseases, Medical Faculty, Yüzüncü Yl University

CORRESPONDENCE: B. Eryonucu, Yüzüncü Yl Üniversitesi, Tp Fakültesi Kardiyoloji AD, 65200, Turkey. Fax: 90 4322168352

Keywords: asthma, heart rate, inhalation, therapeutics

Received: August 28, 2000
Accepted January 17, 2001

This study investigated the effects of ß₂-adrenergic agonist therapy on heart rate variability (HRV) in adult asthmatic patients by using frequency domain measures of HRV.

A randomized crossover design was used. Twenty adult patients with asthma were studied. All patients showed a mild-to-moderate decrease in baseline forced expiratory volume in one second. Any diseases that might have influenced the autonomic function were excluded. All patients had a complete physical examination and medical history that revealed no cardiovascular disease or medication. The study used 200 µg inhaled salbutamol and 500 µg inhaled terbutaline. HRV analysis was performed for each 5-min segment, 5 min before inhalation of the study drug and 5, 10, 15, 20, 25 and 30 min after inhalation. Total power (TP: <0.40 Hz), high-frequency power (HF: 0.15–0.40 Hz), low-frequency power (LF: 0.04–0.15 Hz) and LF/HF ratio were calculated.

The LF and LF/HF ratio increased and TP decreased at 5, 10, 15 and 20 min after the salbutamol and the terbutaline inhalation, HF did not change significantly after the salbutamol and terbutaline inhalation.

Acute salbutamol and terbutaline inhalation produce similar effects on heart rate variability and increase sympathetic modulation in the cardiac autonomic activity.