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1 Dept of Radiology, Johannes GutenbergUniversitaet Mainz, Mainz, Germany, 2 Dept of Medical Biophysics, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada and 3 Section of Academic Radiology, Royal Hallamshire Hospital, Sheffield, UK
CORRESPONDENCE: HU. Kauczor, Klinik und Poliklinik für Radiologie, Universitaet Mainz, Langenbeckstraße 1, DE55131, Mainz, Germany. Fax: 46 6131176633
Keywords: functional lung imaging, hyperpolarization, inert noble gases, nonprotonmagnetic resource imaging, ventilation
Received: April 17, 2001
Accepted April 18, 2001
Abstract
Over the past few years, magnetic resonance imaging (MRI) has emerged as an important instrument for functional ventilation imaging. The aim of this review is to summarize established clinical methods and emerging techniques for research and clinical arenas.
Before the advent of MRI, chest radiography and computed tomography (CT) dominated morphological lung imaging, while functional ventilation imaging was accomplished with scintigraphy. Initially, MRI was not used for morphological lung imaging often, due to technical and physical limitations. However, recent developments have considerably improved anatomical MRI, as well as advanced new techniques in functional ventilation imaging, such as inhaled contrast aerosols, oxygen, hyperpolarized noble gases (Helium-3, Xenon-129), and fluorinated gases (sulphurhexafluoride). Straightforward images demonstrating homogeneity of ventilation and determining ventilated lung volumes can be obtained. Furthermore, new imagederived functional parameters are measurable, such as airspace size, regional oxygen partial pressure, and analysis of ventilation distribution and ventilation/perfusion ratios.
There are several advantages to using MRI: lack of radiation, high spatial and temporal resolution and a broad range of functional information. The MRI technique applied in patients with chronic obstructive pulmonary disease, emphysema, cystic fibrosis, asthma, and bronchiolitis obliterans, may yield a higher sensitivity in the detection of ventilation defects than ventilation scintigraphy, CT or standard pulmonary function tests.
The next step will be to define the threshold between physiological variation and pathological defects. Using complementary strategies, radiologists will have the tools to characterize the impairment of lung function and to improve specificity.
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