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-2b
1 Second and 2 First Medical Dept/Pumologisches Zentrum, 3 Institute for Pathology and Microbiology/Baumgartner Höhe and 4 First Surgical Dept/Krankenanstalt Rudolfstiftung,
CORRESPONDENCE: C. Armbruster, Mantlegasse 23/2/12, A-1130, Vienna, Austria. Fax: 43 18775820
Keywords: bronchoscopy, cidofovir, interferon
-2b, respiratory system, squamous papillomatosis
Received: February 21, 2000
Accepted August 7, 2000
Abstract
In contrast to uncomplicated juvenile laryngeal papillomas which may regress spontaneously, papillomatosis involving pulmonary parenchyma is associated with a poor outcome.
This report represents the case of a 34 yr-old female in whom respiratory papillomatosis resulted in voice problems and recurrent pneumonias due to bronchial obstruction. A computed tomographic scan of the chest showed worsening bilateral round cavitating consolidations. Bronchoscopy revealed polypoid lesions of the right vocal cord and the midtrachea which were confirmed as squamous papillomatosis by histology.
Interferon (IFN)
These data provide support that severe respiratory papillomatosis can be safely treated by interferon
-2b treatment was inefficient as was cidofovir monotherapy on a maintenance basis. Six months of IFN-
-2b and cidofovir in combination led to a complete macroscopic disappearance of the laryngeal lesions and to an impressive regression of the tracheal papillomas and of the intrapulmonary consolidations.
-2b and cidofovir in combination. Probably the same mechanisms as in ribavirin plus interferon
-2b, in the treatment of patients with chronic hepatitis C, are responsible for the therapeutic success in this case.
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