ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Eur Respir J 2001; 17:488-494
Copyright ©ERS Journals Ltd 2001

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Veldhuizen, R.A.W.
Right arrow Articles by McCaig, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Veldhuizen, R.A.W.
Right arrow Articles by McCaig, L.

Effects of mechanical ventilation of isolated mouse lungs on surfactant and inflammatory cytokines

R.A.W. Veldhuizen1,2,3, A.S. Slutsky5, M. Joseph1,3,4 and L. McCaig3

Depts of 1 Medicine, 2 Physiology and the 3 Lawson Research Institute, University of Western Ontario and 4 Dept of Pathology, St Joseph’s Health Centre, London, Canada. 5 Depts of Medicine and Surgery and the Samuel Lunenfeld Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada

CORRESPONDENCE: R. Veldhuizen, Lawson Research Institute, Room G454, 268 Grosvenor Street, London, Ontario, Canada, N6A 4V2. Fax: 1 5196466110

Keywords: ARDS, lung injury, mechanical ventilation, surfactant

Received: November 19, 1999
Accepted May 17, 2000

This work was supported by a grant from the Ontario Thoracic Society.

Mechanical ventilation of the lung is an essential but potentially harmful therapeutic intervention for patients with acute respiratory distress syndrome. The objective of the current study was to establish and characterize an isolated mouse lung model to study the harmful effects of mechanical ventilation.

Lungs were isolated from BalbC mice and randomized to either a nonventilated group, a conventionally ventilated group (tidal volume 7 mL·kg–1, 4 cm positive end-expiratory pressure (PEEP)) or an injuriously ventilated group (20 mL·kg–1, 0 cm PEEP). Lungs were subsequently analysed for lung compliance, morphology, surfactant composition and inflammatory cytokines.

Injurious ventilation resulted in significant lung dysfunction, which was associated with a significant increase in pulmonary surfactant, and surfactant small aggregates compared to the other two groups. Injurious ventilation also led to a significantly increased concentration of interleukin-6 and tumour necrosis factor-{alpha} in the lavage.

It was concluded that the injurious effects of mechanical ventilation can effectively be studied in isolated mouse lung, which offers the potential of studying genetically altered animals. It was also concluded that in this model, the lung injury is, in part, mediated by the surfactant system and the release of inflammatory mediators.




This article has been cited by other articles:


Home page
 Br J AnaesthHome page
N. Soni and P. Williams
Positive pressure ventilation: what is the real cost?
Br. J. Anaesth., October 1, 2008; 101(4): 446 - 457.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. R. Wilson, M. E. Goddard, K. P. O'Dea, S. Choudhury, and M. Takata
Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L60 - L68.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. A. Frank, P. E. Parsons, and M. A. Matthay
Pathogenetic Significance of Biological Markers of Ventilator-Associated Lung Injury in Experimental and Clinical Studies
Chest, December 1, 2006; 130(6): 1906 - 1914.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. R. Chess, M. A. O'Reilly, F. Sachs, and J. N. Finkelstein
Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells
J Appl Physiol, September 1, 2005; 99(3): 1226 - 1232.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, L. A. McCaig, B. Z. Moyer, M. C. Pape, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen
Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L244 - L251.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Ulrich, M. Stern, M. E. Goddard, J. Williams, J. Zhu, A. Dewar, H. A. Painter, P. K. Jeffery, D. R. Gill, S. C. Hyde, et al.
Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury
Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1179 - L1192.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Glaab, W. Mitzner, A. Braun, H. Ernst, R. Korolewitz, J. M. Hohlfeld, N. Krug, and H. G. Hoymann
Repetitive measurements of pulmonary mechanics to inhaled cholinergic challenge in spontaneously breathing mice
J Appl Physiol, September 1, 2004; 97(3): 1104 - 1111.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Kotani, T. Kotani, Z. Li, R. Silbajoris, C.A. Piantadosi, and Y-C.T. Huang
Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch
Eur. Respir. J., August 1, 2004; 24(2): 238 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, B. Z. Moyer, M. C. Pape, B. Starcher, K. J. Leco, and R. A. W. Veldhuizen
Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis
Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1222 - L1232.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Wilson, S. Choudhury, M. E. Goddard, K. P. O'Dea, A. G. Nicholson, and M. Takata
High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury
J Appl Physiol, October 1, 2003; 95(4): 1385 - 1393.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. U. Gurkan, C. O'Donnell, R. Brower, E. Ruckdeschel, and P. M. Becker
Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice
Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L710 - L718.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. P. A. Rasaiah, J. L. Malloy, J. F. Lewis, and R. A. W. Veldhuizen
Early surfactant administration protects against lung dysfunction in a mouse model of ARDS
Am J Physiol Lung Cell Mol Physiol, May 1, 2003; 284(5): L783 - L790.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. C. Bailey, E. L. Martin, L. Zhao, and R. A. W. Veldhuizen
High oxygen concentrations predispose mouse lungsto the deleterious effects of high stretch ventilation
J Appl Physiol, March 1, 2003; 94(3): 975 - 982.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T.C. Bailey, C. Cavanagh, S. Mehta, J.F. Lewis, and R.A.W. Veldhuizen
Sepsis and hyperoxia effects on the pulmonary surfactant system in wild-type and iNOS knockout mice
Eur. Respir. J., July 1, 2002; 20(1): 177 - 182.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the European Respiratory Society.