ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rutgers, S.
Right arrow Articles by Postma, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rutgers, S.
Right arrow Articles by Postma, D.
Eur Respir J 2000; 16: 486-490
Copyright © ERS Journals Ltd 2000

Original Articles

Borg scores before and after challenge with adenosine 5'-monophosphate and methacholine in subjects with COPD and asthma

SR Rutgers, NH ten Hacken, GH Koeter, and DS Postma

Dyspnoea differs between subjects with chronic obstructive pulmonary disease (COPD) and asthma, partly because the underlying mechanisms for bronchoconstriction differ. This study investigated the possible role of inflammation and the contribution of clinical variables on dyspnoea in subjects with COPD and asthma. Forty-eight smoking subjects with COPD and 21 nonsmoking subjects with asthma, were challenged with adenosine 5'-monophosphate (AMP) and methacholine. The Borg score was assessed before and after each challenge. Mean increases in Borg score (per percentage decrease in baseline forced expiratory volume in one second (FEV1)) were significantly smaller in COPD than in asthma (p<0.01), values being 0.055 and 0.045 in COPD and 0.122 and 0.093 in asthma respectively. This difference was largely due to the fact that one-third of the subjects with COPD did not increase their Borg score during bronchoconstriction. The increase in Borg tended to be larger during AMP than during methacholine challenge, both in asthma and COPD. Changes in Borg scores were explained by age in COPD and by the Borg score before AMP challenge in asthma. The authors conclude that perception of dyspnoea during adenosine 5'-monophosphate and methacholine induced bronchoconstriction is lower in chronic obstructive pulmonary disease than in asthma and that age contributes to this difference. As adenosine 5'-monophosphate is regarded as an indirect marker of airway inflammation, the results suggest that inflammation is not important because both groups showed similar responses on such provocations.


This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
K. F. Rabe
Improving Dyspnea in Chronic Obstructive Pulmonary Disease: Optimal Treatment Strategies
Proceedings of the ATS, May 1, 2006; 3(3): 270 - 275.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L.-P. Boulet, C. Lemiere, F. Archambault, G. Carrier, M. C. Descary, and F. Deschesnes
Smoking and Asthma: Clinical and Radiologic Features, Lung Function, and Airway Inflammation
Chest, March 1, 2006; 129(3): 661 - 668.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
O. K. Basoglu, A. Pelleg, S. Essilfie-Quaye, C. Brindicci, P. J. Barnes, and S. A. Kharitonov
Effects of Aerosolized Adenosine 5'-Triphosphate vs Adenosine 5'-Monophosphate on Dyspnea and Airway Caliber in Healthy Nonsmokers and Patients With Asthma
Chest, October 1, 2005; 128(4): 1905 - 1909.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. TAUBE, O. HOLZ, M. MUCKE, R. A. JORRES, and H. MAGNUSSEN
Airway Response to Inhaled Hypertonic Saline in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1810 - 1815.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the European Respiratory Society.