| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Articles |
Bronchoalveolar lavage fluids (BALF) from patients with idiopathic pulmonary fibrosis (IPF; n=36), hypersensitivity pneumonitis (HP; n=32) and sarcoidosis (n=44) were investigated for their surfactant properties and compared to healthy control subjects (n=29). The phospholipid (PL) and protein concentration, the PL:protein ratio, PL subclasses, and the surfactant apoproteins (SP)A and SP-B were quantified in BALF. Large surfactant aggregates (LSA) were measured by means of ultracentrifugation and assayed for surface activity using the pulsating bubble surfactometer. As compared to controls, SP-A concentrations, LSA content and PL:protein ratios were significantly decreased in all groups, whereas PL and SP-B concentrations remained unchanged. Changes in the phospholipid profile, with reduced percentages of phosphatidylcholine (not significant) and phosphatidylglycerol and increased fractions of phosphatidylinositol and sphingomyelin (p<0.05), occurred more in IPF than in HP, and not in sarcoidosis. Surface activity was found to be severely impaired in IPF (minimum surface tension (gamma min) approximately 15-20 mN x m(-1)), but only modestly affected in HP and sarcoidosis (gamma min approximately 5 mN x m(-1)) compared to controls (gamma min approximately 0 mN x m(-1)). Reconstitution of pelleted surfactant material with soluble BALF proteins further increased gamma min values. In conclusion, moderate changes in biochemical and physical surfactant properties are encountered in hypersensitivity pneumonitis and sarcoidosis, but pronounced disturbances occur in idiopathic pulmonary fibrosis.
This article has been cited by other articles:
|
|
 |
|
  L. L. Koth, B. Alex, S. Hawgood, M. A. Nead, D. Sheppard, D. J. Erle, and D. G. Morris Integrin beta6 Mediates Phospholipid and Collectin Homeostasis by Activation of Latent TGF-beta1 Am. J. Respir. Cell Mol. Biol., December 1, 2007; 37(6): 651 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gunther, B. Enke, P. Markart, P. Hammerl, H. Morr, J. Behr, G. Stahler, W. Seeger, F. Grimminger, I. Leconte, et al. Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study Eur. Respir. J., April 1, 2007; 29(4): 713 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Phelps, T. M. Umstead, M. Mejia, G. Carrillo, A. Pardo, and M. Selman Increased Surfactant Protein-A Levels in Patients With Newly Diagnosed Idiopathic Pulmonary Fibrosis Chest, February 1, 2004; 125(2): 617 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gunther, N. Lubke, M. Ermert, R. T. Schermuly, N. Weissmann, A. Breithecker, P. Markart, C. Ruppert, K. Quanz, L. Ermert, et al. Prevention of Bleomycin-induced Lung Fibrosis by Aerosolization of Heparin or Urokinase in Rabbits Am. J. Respir. Crit. Care Med., December 1, 2003; 168(11): 1358 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Ballard, J. D. Merrill, R. I. Godinez, M. H. Godinez, W. E. Truog, and R. A. Ballard Surfactant Protein Profile of Pulmonary Surfactant in Premature Infants Am. J. Respir. Crit. Care Med., November 1, 2003; 168(9): 1123 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Friedrich, J. Spillner, E.-X. Lu, M. Barnscheidt, O. Kuss, A. Sablotzki, F. U. Schade, and J. Borgermann Induction of endotoxin tolerance improves lung function after warm ischemia in dogs Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L224 - L231. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
