| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Articles |
Interleukin (IL)-18 is an interferon (IFN)-gamma-inducing cytokine suggested to be important in regulating inflammatory responses. This study investigated the pulmonary expression of IL-18 under conditions characterized by T-helper (Th)1 (lipopolysaccharide (LPS) treatment/sarcoidosis) and Th2 (ovalbumin (OVA) challenge/asthma) cytokine production. In situ hybridization and immunocytochemistry were used to determine the number of cells expressing IL-18, IFN-gamma, IL-5 and major basic protein (MBP) within lung tissue from Balb/c mice stimulated with LPS, OVA and in normal control mice. Bronchial biopsies from patients with sarcoidosis, asthma and control individuals were also examined. IL-18 was localized primarily to airway epithelium and mononuclear cells. Constitutive expression was observed within the lungs of control mice. Animals challenged with LPS exhibited more IL-18 messenger ribonucleic acid (mRNA)-positive and IFN-gamma immunoreactive cells, compared to control mice (p<0.01). OVA-challenged mice had fewer IL-18 mRNA positive and more IL-5 and MBP immunoreactive cells, compared to control mice (p<0.01). Similarly, constitutive expression of IL-18 protein was observed within the airway epithelium of control individuals, with more positive cells found within sarcoidosis tissue (p<0.01) and fewer within asthmatic tissue (p<0.01), compared to controls. These results demonstrate the expression of interleukin-18 within airway epithelium and the regulation of this cytokine under conditions of both T-helper1 and T-helper2 cytokine production.
This article has been cited by other articles:
|
|
 |
|
  M. Lochner, K. Kastenmuller, M. Neuenhahn, H. Weighardt, D. H. Busch, W. Reindl, and I. Forster Decreased Susceptibility of Mice to Infection with Listeria monocytogenes in the Absence of Interleukin-18 Infect. Immun., September 1, 2008; 76(9): 3881 - 3890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-O. Larsen, B. Lygren, I. Sjaastad, K. A. Krobert, K. Arnkvaern, G. Florholmen, A.-K. R. Larsen, F. O. Levy, K. Tasken, O. H. Skjonsberg, et al. Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A Cardiovasc Res, July 29, 2008; (2008) cvn180v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-J. Kang, R. J. Homer, A. Gallo, C. G. Lee, K. A. Crothers, S. J. Cho, C. Rochester, H. Cain, G. Chupp, H. J. Yoon, et al. IL-18 Is Induced and IL-18 Receptor {alpha} Plays a Critical Role in the Pathogenesis of Cigarette Smoke-Induced Pulmonary Emphysema and Inflammation J. Immunol., February 1, 2007; 178(3): 1948 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Lee, S. R. Kim, S. J. Park, K. H. Min, K. Y. Lee, S. M. Jin, W. H. Yoo, and Y. C. Lee Antioxidant Down-Regulates Interleukin-18 Expression in Asthma Mol. Pharmacol., October 1, 2006; 70(4): 1184 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ishikawa, T. Yoshimoto, and K. Nakanishi Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness Int. Immunol., June 1, 2006; 18(6): 847 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Kelly, C. M. Greene, G. Meachery, M. O'Mahony, P. M. Gallagher, C. C. Taggart, S. J. O'Neill, and N. G. McElvaney Endotoxin Up-regulates Interleukin-18: Potential Role for Gram-Negative Colonization in Sarcoidosis Am. J. Respir. Crit. Care Med., November 15, 2005; 172(10): 1299 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sasaki, T. Yoshimoto, H. Maruyama, T. Tegoshi, N. Ohta, N. Arizono, and K. Nakanishi IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity J. Exp. Med., September 6, 2005; 202(5): 607 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nakatani-Okuda, H. Ueda, S.-i. Kashiwamura, A. Sekiyama, A. Kubota, Y. Fujita, S. Adachi, Y. Tsuji, T. Tanizawa, and H. Okamura Protection against bleomycin-induced lung injury by IL-18 in mice Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L280 - L287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kitasato, T. Hoshino, M. Okamoto, S. Kato, Y. Koda, N. Nagata, M. Kinoshita, H. Koga, D.-Y. Yoon, H. Asao, et al. Enhanced Expression of Interleukin-18 and its Receptor in Idiopathic Pulmonary Fibrosis Am. J. Respir. Cell Mol. Biol., December 1, 2004; 31(6): 619 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hata, T. Yoshimoto, N. Hayashi, T. Hada, and K. Nakanishi IL-18 together with anti-CD3 antibody induces human Th1 cells to produce Th1- and Th2-cytokines and IL-8 Int. Immunol., December 1, 2004; 16(12): 1733 - 1739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Z. Wang, Y.-X. Bao, C. L. Rosenberger, Y. Tesfaigzi, J. M. Stark, and K. S. Harrod IL-12p40 and IL-18 Modulate Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection J. Immunol., September 15, 2004; 173(6): 4040 - 4049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sugimoto, Y. Ishikawa, T. Yoshimoto, N. Hayashi, J. Fujimoto, and K. Nakanishi Interleukin 18 Acts on Memory T Helper Cells Type 1 to Induce Airway Inflammation and Hyperresponsiveness in a Naive Host Mouse J. Exp. Med., February 17, 2004; 199(4): 535 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Liu, I. Mori, M. J. Hossain, L. Dong, K. Takeda, and Y. Kimura Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity J. Gen. Virol., February 1, 2004; 85(2): 423 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Segel, G. Izbicki, P. Y. Cohen, R. Or, T. G. Christensen, S. B. Wallach-Dayan, and R. Breuer Role of interferon-{gamma} in the evolution of murine bleomycin lung fibrosis Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1255 - L1262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Reading and G. L. Smith Vaccinia Virus Interleukin-18-Binding Protein Promotes Virulence by Reducing Gamma Interferon Production and Natural Killer and T-Cell Activity J. Virol., September 15, 2003; 77(18): 9960 - 9968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Taha, Q. Hamid, L. Cameron, and R. Olivenstein T Helper Type 2 Cytokine Receptors and Associated Transcription Factors GATA-3, c-MAF, and Signal Transducer and Activator of Transcription Factor-6 in Induced Sputum of Atopic Asthmatic Patients Chest, June 1, 2003; 123(6): 2074 - 2082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nakano, H. Tsutsui, M. Terada, K. Yasuda, K. Matsui, S. Yumikura-Futatsugi, K.-i. Yamanaka, H. Mizutani, T. Yamamura, and K. Nakanishi Persistent secretion of IL-18 in the skin contributes to IgE response in mice Int. Immunol., May 1, 2003; 15(5): 611 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-P. Ho, M. Davis, A. Denison, F. T. Wood, and A. P. Greening Reduced Interleukin-18 Levels in BAL Specimens From Patients With Asthma Compared to Patients With Sarcoidosis and Healthy Control Subjects* Chest, May 1, 2002; 121(5): 1421 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. N. Lauw, J. Branger, S. Florquin, P. Speelman, S. J. H. van Deventer, S. Akira, and T. van der Poll IL-18 Improves the Early Antimicrobial Host Response to Pneumococcal Pneumonia J. Immunol., January 1, 2002; 168(1): 372 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hyun Kim, L. L. Reznikov, R. J. L. Stuyt, C. H. Selzman, G. Fantuzzi, T. Hoshino, H. A. Young, and C. A. Dinarello Functional Reconstitution and Regulation of IL-18 Activity by the IL-18R{beta} Chain J. Immunol., January 1, 2001; 166(1): 148 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shigehara, N. Shijubo, M. Ohmichi, R. Takahashi, S.-i. Kon, H. Okamura, M. Kurimoto, Y. Hiraga, T. Tatsuno, S. Abe, et al. IL-12 and IL-18 Are Increased and Stimulate IFN-{{gamma}} Production in Sarcoid Lungs J. Immunol., January 1, 2001; 166(1): 642 - 649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Narita, H. Tanaka, S. Abe, S. Yamada, M. Kubota, and T. Togashi Close Association between Pulmonary Disease Manifestation in Mycoplasma pneumoniae Infection and Enhanced Local Production of Interleukin-18 in the Lung, Independent of Gamma Interferon Clin. Vaccine Immunol., November 1, 2000; 7(6): 909 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Greene, G. Meachery, C. C. Taggart, C. P. Rooney, R. Coakley, S. J. O'Neill, and N. G. McElvaney Role of IL-18 in CD4+ T Lymphocyte Activation in Sarcoidosis J. Immunol., October 15, 2000; 165(8): 4718 - 4724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Wild, A. Sigounas, N. Sur, M. S. Siddiqui, R. Alam, M. Kurimoto, and S. Sur IFN-{gamma}-Inducing Factor (IL-18) Increases Allergic Sensitization, Serum IgE, Th2 Cytokines, and Airway Eosinophilia in a Mouse Model of Allergic Asthma J. Immunol., March 1, 2000; 164(5): 2701 - 2710. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
