ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Eur Respir J 1999; 13:1070-1077
Copyright ©ERS Journals Ltd 1999

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lecarpentier, Y
Right arrow Articles by Mercadier, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lecarpentier, Y
Right arrow Articles by Mercadier, J.

Original Articles

Diaphragm strength and cross-bridge properties during chronic growth hormone hypersecretion

Y Lecarpentier, C Coirault, B Riou, D Chemla, and JJ Mercadier

The aim of the study was to determine diaphragm performance and cross-bridge properties in rats bearing a growth hormone (GH)-secreting tumour. The tumour was induced by subcutaneous injection of GH-hypersecreting cells (GC cells) into the flank. Eighteen weeks after GC cell injection, rats developed a GH-secreting tumour (45.4+/-5.1 g) and the GH plasma level reached 5,408+/-648 microg x L(-1) in GH rats versus 7.2+/-2.2 microg x L(-1) in control rats (p<0.001). Diaphragm mechanics and cross-bridge properties were studied by applying the equations of A. Huxley in isolated diaphragm strips (control rats: n=12; GH rats n=20). In comparison to control rats, the total tension and total number of cross-bridges x mm(-2) in GH rats were lower in both twitch and tetanus (p<0.001). A linear relationship was observed between total tension and total cross-bridge number (r=0.94; p<0.001). Conversely, the cross-bridge single force and peak mechanical efficiency did not differ between control and GH rats, in either twitch or tetanus modes. In conclusion, the diaphragm strength was significantly lower in rats bearing growth hormone secreting tumours, and this was essentially determined by the lower cross-bridge number x mm(-2) without change in cross-bridge single force.


This article has been cited by other articles:


Home page
 Eur Respir JHome page
P. Attal, V. Claes, S. Bobin, P. Chanson, P. Kamenicky, P. Zizzari, and Y. Lecarpentier
Growth hormone excess and sternohyoid muscle mechanics in rats
Eur. Respir. J., October 1, 2009; 34(4): 967 - 974.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
O. Langeron, B. Bouhemad, G. Orliaguet, P. Coriat, Y. Lecarpentier, and B. Riou
Effects of halogenated anaesthetics on diaphragmatic actin-myosin cross-bridge kinetics
Br. J. Anaesth., June 1, 2003; 90(6): 759 - 765.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Orliaguet, O. Langeron, B. Bouhemad, P. Coriat, Y. LeCarpentier, and B. Riou
Effects of postnatal maturation on energetics and cross-bridge properties in rat diaphragm
J Appl Physiol, March 1, 2002; 92(3): 1074 - 1082.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Lecarpentier, D. Chemla, J. C. Pourny, F.-X. Blanc, and C. Coirault
Myosin cross bridges in skeletal muscles: "rower" molecular motors
J Appl Physiol, December 1, 2001; 91(6): 2479 - 2486.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the European Respiratory Society.