Reactive oxygen species in acute lung injury

The acute respiratory distress syndrome (ARDS) in adults is associated with a wide variety of precipitating factors, often not directly involving the lung, and has an associated mortality of 50-80%. ARDS is almost invariably associated with sepsis, either as an initiating factor or as a secondary complication, which increases the expression of a number of cytokines impacting upon several cellular systems. Specifically, activation of neutrophils sequestered in the pulmonary circulation by this process, causes the release of free radicals and reactive oxygen species (ROS), increasingly regarded as key substances modulating the endothelial dysfunction and disruption responsible for the principal clinical manifestations of the syndrome. Here we discuss briefly the pathophysiology of ARDS and its impact upon pulmonary vascular control; the biological origins of free radicals and other ROS involved, the mechanisms of their damaging effects, their contribution to the modification of pulmonary vascular control mechanisms in lung injury and possible therapeutic perspectives.

This article has been cited by other articles:

				N. M. Reddy, V. Suryanarayana, D. V. Kalvakolanu, M. Yamamoto, T. W. Kensler, P. M. Hassoun, S. R. Kleeberger, and S. P. Reddy Innate Immunity against Bacterial Infection following Hyperoxia Exposure Is Impaired in NRF2-Deficient Mice J. Immunol., October 1, 2009; 183(7): 4601 - 4608. [Abstract] [Full Text] [PDF]

				K. S. Farley, L. Wang, and S. Mehta Septic pulmonary microvascular endothelial cell injury: role of alveolar macrophage NADPH oxidase Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L480 - L488. [Abstract] [Full Text] [PDF]

				A. A. Birukova, E. Alekseeva, I. Cokic, C. E. Turner, and K. G. Birukov Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids Am J Physiol Lung Cell Mol Physiol, October 1, 2008; 295(4): L593 - L602. [Abstract] [Full Text] [PDF]

				J. W. Zmijewski, E. Lorne, X. Zhao, Y. Tsuruta, Y. Sha, G. Liu, G. P. Siegal, and E. Abraham Mitochondrial Respiratory Complex I Regulates Neutrophil Activation and Severity of Lung Injury Am. J. Respir. Crit. Care Med., July 15, 2008; 178(2): 168 - 179. [Abstract] [Full Text] [PDF]

				S. Papaiahgari, A. Yerrapureddy, S. R. Reddy, N. M. Reddy, J. M. Dodd-O, M. T. Crow, D. N. Grigoryev, K. Barnes, R. M. Tuder, M. Yamamoto, et al. Genetic and Pharmacologic Evidence Links Oxidative Stress to Ventilator-induced Lung Injury in Mice Am. J. Respir. Crit. Care Med., December 15, 2007; 176(12): 1222 - 1235. [Abstract] [Full Text] [PDF]

				A. A. Birukova, P. Fu, S. Chatchavalvanich, D. Burdette, O. Oskolkova, V. N. Bochkov, and K. G. Birukov Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L924 - L935. [Abstract] [Full Text] [PDF]

				D. Xu, J. R. Guthrie, S. Mabry, T. M. Sack, and W. E. Truog Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L966 - L975. [Abstract] [Full Text] [PDF]

				S. Nonas, I. Miller, K. Kawkitinarong, S. Chatchavalvanich, I. Gorshkova, V. N. Bochkov, N. Leitinger, V. Natarajan, J. G. N. Garcia, and K. G. Birukov Oxidized Phospholipids Reduce Vascular Leak and Inflammation in Rat Model of Acute Lung Injury Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1130 - 1138. [Abstract] [Full Text] [PDF]

				A. M. Siore, R. E. Parker, A. A. Stecenko, C. Cuppels, M. McKean, B. W. Christman, R. Cruz-Gervis, and K. L. Brigham Endotoxin-induced acute lung injury requires interaction with the liver Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L769 - L776. [Abstract] [Full Text] [PDF]

				P. Pilo, E. M. Vilei, E. Peterhans, L. Bonvin-Klotz, M. H. Stoffel, D. Dobbelaere, and J. Frey A Metabolic Enzyme as a Primary Virulence Factor of Mycoplasma mycoides subsp. mycoides Small Colony J. Bacteriol., October 1, 2005; 187(19): 6824 - 6831. [Abstract] [Full Text] [PDF]

				S.-J. Chu, W.-C. Perng, C.-M. Hung, D.-M. Chang, S.-H. Lin, and K.-L. Huang Effects of Various Body Temperatures After Lipopolysaccharide-Induced Lung Injury in Rats Chest, July 1, 2005; 128(1): 327 - 336. [Abstract] [Full Text] [PDF]

				S Muzaffar, N Shukla, G D Angelini, and J Y Jeremy Acute hypoxia simultaneously induces the expression of gp91phox and endothelial nitric oxide synthase in the porcine pulmonary artery Thorax, April 1, 2005; 60(4): 305 - 313. [Abstract] [Full Text] [PDF]

				S. Jeyaseelan, H. W. Chu, S. K. Young, M. W. Freeman, and G. S. Worthen Distinct Roles of Pattern Recognition Receptors CD14 and Toll-Like Receptor 4 in Acute Lung Injury Infect. Immun., March 1, 2005; 73(3): 1754 - 1763. [Abstract] [Full Text] [PDF]

				K. P. Grichnik and T. A. D'Amico Acute Lung Injury and Acute Respiratory Distress Syndrome After Pulmonary Resection Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2004; 8(4): 317 - 334. [Abstract] [PDF]

				S. Jeyaseelan, H. W. Chu, S. K. Young, and G. S. Worthen Transcriptional Profiling of Lipopolysaccharide-Induced Acute Lung Injury Infect. Immun., December 1, 2004; 72(12): 7247 - 7256. [Abstract] [Full Text] [PDF]

				K. G. Birukov, V. N. Bochkov, A. A. Birukova, K. Kawkitinarong, A. Rios, A. Leitner, A. D. Verin, G. M. Bokoch, N. Leitinger, and Joe. G.N. Garcia Epoxycyclopentenone-Containing Oxidized Phospholipids Restore Endothelial Barrier Function via Cdc42 and Rac Circ. Res., October 29, 2004; 95(9): 892 - 901. [Abstract] [Full Text] [PDF]

				S. Muzaffar, N. Shukla, G. Angelini, and J. Y. Jeremy Nitroaspirins and Morpholinosydnonimine but Not Aspirin Inhibit the Formation of Superoxide and the Expression of gp91phox Induced by Endotoxin and Cytokines in Pig Pulmonary Artery Vascular Smooth Muscle Cells and Endothelial Cells Circulation, August 31, 2004; 110(9): 1140 - 1147. [Abstract] [Full Text] [PDF]

				T. Geiser, M. Ishigaki, C. van Leer, M. A. Matthay, and V. C. Broaddus H2O2 inhibits alveolar epithelial wound repair in vitro by induction of apoptosis Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L448 - L453. [Abstract] [Full Text] [PDF]

				E. D. Moloney and M. J. D. Griffiths Protective ventilation of patients with acute respiratory distress syndrome Br. J. Anaesth., February 1, 2004; 92(2): 261 - 270. [Abstract] [Full Text] [PDF]

				M. Christofidou-Solomidou, A. Scherpereel, R. Wiewrodt, K. Ng, T. Sweitzer, E. Arguiri, V. Shuvaev, C. C. Solomides, S. M. Albelda, and V. R. Muzykantov PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L283 - L292. [Abstract] [Full Text] [PDF]

				S. V. Baudouin Lung injury after thoracotomy Br. J. Anaesth., July 1, 2003; 91(1): 132 - 142. [Full Text] [PDF]

				S Muzaffar, J Y Jeremy, G D Angelini, K Stuart-Smith, and N Shukla Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries Thorax, July 1, 2003; 58(7): 598 - 604. [Abstract] [Full Text] [PDF]

				S. Perkowski, J. Sun, S. Singhal, J. Santiago, G. D. Leikauf, and S. M. Albelda Gene Expression Profiling of the Early Pulmonary Response to Hyperoxia in Mice Am. J. Respir. Cell Mol. Biol., June 1, 2003; 28(6): 682 - 696. [Abstract] [Full Text] [PDF]

				K. Mayer, S. Gokorsch, C. Fegbeutel, K. Hattar, S. Rosseau, D. Walmrath, W. Seeger, and F. Grimminger Parenteral Nutrition with Fish Oil Modulates Cytokine Response in Patients with Sepsis Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1321 - 1328. [Abstract] [Full Text] [PDF]

				T. Ruan, C.-Y. Ho, and Y. R. Kou Afferent vagal pathways mediating respiratory reflexes evoked by ROS in the lungs of anesthetized rats J Appl Physiol, May 1, 2003; 94(5): 1987 - 1998. [Abstract] [Full Text] [PDF]

				K. SATO, M. B. KADIISKA, A. J. GHIO, J. CORBETT, Y. C. FANN, S. M. HOLLAND, R. G. THURMAN, and R. P. MASON In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS FASEB J, November 1, 2002; 16(13): 1713 - 1720. [Abstract] [Full Text] [PDF]

				H Yasuda, M Yamaya, M Yanai, T Ohrui, and H Sasaki Increased blood carboxyhaemoglobin concentrations in inflammatory pulmonary diseases Thorax, September 1, 2002; 57(9): 779 - 783. [Abstract] [Full Text] [PDF]

				J Cranshaw, M J D Griffiths, and T W Evans The pulmonary physician in critical care c 9: Non-ventilatory strategies in ARDS Thorax, September 1, 2002; 57(9): 823 - 829. [Abstract] [Full Text] [PDF]

				T Whitehead and A S Slutsky The pulmonary physician in critical care * 7: Ventilator induced lung injury Thorax, July 1, 2002; 57(7): 635 - 642. [Abstract] [Full Text] [PDF]

				K. Mayer, R. Schmidt, M. Muhly-Reinholz, T. Bogeholz, S. Gokorsch, F. Grimminger, and W. Seeger In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNF{alpha} impact of {omega}-3 versus {omega}-6 fatty acids J. Lipid Res., June 1, 2002; 43(6): 944 - 951. [Abstract] [Full Text] [PDF]

				Y. Ouadrhiri, C. Pilette, R. C. Monteiro, J.-P. Vaerman, and Y. Sibille Effect of IgA on Respiratory Burst and Cytokine Release by Human Alveolar Macrophages . Role of ERK1/2 Mitogen-Activated Protein Kinases and NF-kappa B Am. J. Respir. Cell Mol. Biol., March 1, 2002; 26(3): 315 - 332. [Abstract] [Full Text] [PDF]

				M. Christofidou-Solomidou, G. G. Pietra, C. C. Solomides, E. Arguiris, D. Harshaw, G. A. Fitzgerald, S. M. Albelda, and V. R. Muzykantov Immunotargeting of glucose oxidase to endothelium in vivo causes oxidative vascular injury in the lungs Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L794 - L805. [Abstract] [Full Text] [PDF]

				J.Y. Jeremy, G.D. Angelini, M. Khan, D.P. Mikhailidis, R.J. Morgan, C.S. Thompson, K.R. Bruckdorfer, and K.M. Naseem Platelets, oxidant stress and erectile dysfunction: an hypothesis Cardiovasc Res, April 1, 2000; 46(1): 50 - 54. [Full Text] [PDF]

				H.-C. Wang, M. D. Zentner, H.-T. Deng, K.-J. Kim, R. Wu, P.-C. Yang, and D. K. Ann Oxidative Stress Disrupts Glucocorticoid Hormone-dependent Transcription of the Amiloride-sensitive Epithelial Sodium Channel alpha -Subunit in Lung Epithelial Cells through ERK-dependent and Thioredoxin-sensitive Pathways J. Biol. Chem., March 17, 2000; 275(12): 8600 - 8609. [Abstract] [Full Text] [PDF]

				M. D. Wheeler and R. G. Thurman Production of superoxide and TNF-alpha from alveolar macrophages is blunted by glycine Am J Physiol Lung Cell Mol Physiol, November 1, 1999; 277(5): L952 - L959. [Abstract] [Full Text] [PDF]

				G. Asimakopoulos, P. L.C. Smith, C. P. Ratnatunga, and K. M. Taylor Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass Ann. Thorac. Surg., September 1, 1999; 68(3): 1107 - 1115. [Abstract] [Full Text] [PDF]

				J. J. E. Haddad, R. E. Olver, and S. C. Land Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1alpha and NF-kappa B Redox Sensitivity. EVIDENCE FOR INHIBITION BY GLUTATHIONE OXIDATION IN ALVEOLAR EPITHELIAL CELLS J. Biol. Chem., July 7, 2000; 275(28): 21130 - 21139. [Abstract] [Full Text] [PDF]