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Eur Respir J 1998; 11: 501-503
Copyright © ERS Journals Ltd 1998

Case Studies

Early-onset phenytoin toxicity mimicking a renopulmonary syndrome

AJ Polman, TS van der Werf, AT Tiebosch, and JG Zijlstra

Phenytoin is a commonly used anti-epileptic drug. Adverse reactions including fever, skin reactions and lymphadenopathy are well known but atypical reactions can also occur. A patient is described with a lag time of only 4 days between onset of phenytoin and the development of a syndrome with acute lung injury and renal failure. The symptoms mimicked a renopulmonary syndrome, and resolved completely after cessation of phenytoin and addition of steroids.


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