| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Articles |
Several recent observations suggest that tachykinins, such as substance P and neurokinin A, might be involved in the pathogenesis of bronchopulmonary alterations. Progress in investigations on the physiological and pathological roles of tachykinins has been greatly facilitated by the availability of a number of highly selective nonpeptide antagonists for tachykinin neurokinin 1, 2 and 3 (NK1, NK2 and NK3) receptors. The use of selective tachykinin NK2 receptor antagonists suggests that tachykinin NK2 receptor stimulation plays an important role in the development of airway hyperresponsiveness in the guinea-pig. Others studies have also indicated that tachykinin NK1-receptors are involved in immediate or delayed neurogenic inflammation including microvascular leakage and the subsequent increase in plasma protein extravasation. A role for the sensory neuropeptide system has also been proposed in cough, as shown by the observation that the antitussive effect of tachykinin NK2 receptor antagonists has clearly been demonstrated in several experimental conditions, but the effect of tachykinin NK1 receptor antagonists is still debated. Taken together, the results obtained with the various selective receptor antagonists provide pharmacological evidence that tachykinins play a role in delayed bronchopulmonary alterations and suggest that tachykinin receptor antagonists may be useful for investigating mechanisms and possibly reducing airway functional alterations in asthmatic patients.
This article has been cited by other articles:
|
|
 |
|
  J. Hara, M. Fujimura, A. Ueda, S. Myou, Y. Oribe, N. Ohkura, T. Kita, M. Yasui, and K. Kasahara Effect of Pressure Stress Applied to the Airway on Cough-Reflex Sensitivity in Guinea Pigs Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 585 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Mizuta, G. Gallos, D. Zhu, F. Mizuta, F. Goubaeva, D. Xu, R. A. Panettieri Jr., J. Yang, and C. W. Emala Sr. Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells Am J Physiol Lung Cell Mol Physiol, March 1, 2008; 294(3): L523 - L534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N Patterson, B. T Johnston, J. E S Ardill, L. G Heaney, and L. P A McGarvey Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid reflux Thorax, June 1, 2007; 62(6): 491 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Boot, S. de Haas, S. Tarasevych, C. Roy, L. Wang, D. Amin, J. Cohen, P. J. Sterk, B. Miller, A. Paccaly, et al. Effect of an NK1/NK2 Receptor Antagonist on Airway Responses and Inflammation to Allergen in Asthma Am. J. Respir. Crit. Care Med., March 1, 2007; 175(5): 450 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. V. Dicpinigaitis Potential Future Therapies for the Management of Cough: ACCP Evidence-Based Clinical Practice Guidelines Chest, January 1, 2006; 129(1_suppl): 284S - 286S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.H. Morice and committee members The diagnosis and management of chronic cough Eur. Respir. J., September 1, 2004; 24(3): 481 - 492. [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Canning, S. B. Mazzone, S. N. Meeker, N. Mori, S. M. Reynolds, and B. J. Undem Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs J. Physiol., June 1, 2004; 557(2): 543 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.F. Joos, W. Vincken, R. Louis, V.J. Schelfhout, J.H. Wang, M.J. Shaw, G.D. Cioppa, and R.A. Pauwels Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients Eur. Respir. J., January 1, 2004; 23(1): 76 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P V Dicpinigaitis Cough {middle dot} 4: Cough in asthma and eosinophilic bronchitis Thorax, January 1, 2004; 59(1): 71 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-Y. Huang and Y.-L. Lai Lipopolysaccharide Induces Preprotachykinin Gene Expression Am. J. Respir. Cell Mol. Biol., November 1, 2003; 29(5): 606 - 612. [Abstract] [Full Text]
|
|
|
|
|
|
P. V. Dicpinigaitis Cough Reflex Sensitivity in Cigarette Smokers Chest, March 1, 2003; 123(3): 685 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Teramoto, H. Tanaka, S. Kaneko, and S. Abe Neurokinin-1 and Neurokinin-2 Antagonism Inhibits Long-term Acid Fog-Induced Airway Hyperresponsiveness Chest, February 1, 2003; 123(2): 524 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Emonds-Alt, V. Proietto, R. Steinberg, F. Oury-Donat, X. Vige, P. Vilain, E. Naline, S. Daoui, C. Advenier, G. Le Fur, et al. SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}- 4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin-1 Receptor: I. Biochemical and Pharmacological Characterization J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 1171 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Canning, S. M. Reynolds, L. U. Anukwu, R. Kajekar, and A. C. Myers Endogenous neurokinins facilitate synaptic transmission in guinea pig airway parasympathetic ganglia Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R320 - R330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Mazzone and B. J. Canning Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R86 - R98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. J. Van Rensen, P. S. Hiemstra, K. F. Rabe, and P. J. Sterk Assessment of Microvascular Leakage via Sputum Induction: The Role of Substance P and Neurokinin A in Patients with Asthma Am. J. Respir. Crit. Care Med., May 1, 2002; 165(9): 1275 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Canning, S. M. Reynolds, and S. B. Mazzone Multiple mechanisms of reflex bronchospasm in guinea pigs J Appl Physiol, December 1, 2001; 91(6): 2642 - 2653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. SCHMIDLIN, S. AMADESI, R. VIDIL, M. TREVISANI, N. MARTINET, G. CAUGHEY, M. TOGNETTO, G. CAVALLESCO, C. MAPP, P. GEPPETTI, et al. Expression and Function of Proteinase-activated Receptor 2 in Human Bronchial Smooth Muscle Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1276 - 1281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. AMADESI, J. MOREAU, M. TOGNETTO, J. SPRINGER, M. TREVISANI, E. NALINE, C. ADVENIER, A. FISHER, D. VINCI, C. MAPP, et al. NK1 Receptor Stimulation Causes Contraction and Inositol Phosphate Increase in Medium-size Human Isolated Bronchi Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1206 - 1211. [Abstract] [Full Text]
|
|
|
|
|
|
P V DICPINIGAITIS and P M A CALVERLEY Capsaicin responsiveness in asthma and COPD Thorax, February 1, 2001; 56(2): 161b - 161. [Full Text]
|
|
|
|
|
|
F. L. M. RICCIARDOLO, M. STEINHOFF, S. AMADESI, R. GUERRINI, M. TOGNETTO, M. TREVISANI, C. CREMINON, C. BERTRAND, N. W. BUNNETT, L. M. FABBRI, et al. Presence and Bronchomotor Activity of Protease-Activated Receptor-2 in Guinea Pig Airways Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1672 - 1680. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. M. Pinto, C. P. Armesto, J. Magraner, M. Trujillo, J. D. MartÍn, and M. Luz Candenas Tachykinin Receptor and Neutral Endopeptidase Gene Expression in the Rat Uterus: Characterization and Regulation in Response to Ovarian Steroid Treatment Endocrinology, June 1, 1999; 140(6): 2526 - 2532. [Abstract] [Full Text]
|
|
|
|
|
|
H. HOSHINO, J. LOTVALL, B.-E. SKOOGH, and A. LINDEN Neutrophil Recruitment by Interleukin-17 into Rat Airways In Vivo . Role of Tachykinins Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1423 - 1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. SCHUILING, A. B. ZUIDHOF, J. ZAAGSMA, and H. MEURS Involvement of Tachykinin NK1 Receptor in the Development of Allergen-induced Airway Hyperreactivity and Airway Inflammation in Conscious, Unrestrained Guinea Pigs Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 423 - 430. [Abstract] [Full Text]
|
|
|
|
|
|
A. N. Passannante, M. J. Hazucha, P. A. Bromberg, E. Seal, L. Folinsbee, and G. Koch Nociceptive mechanisms modulate ozone-induced human lung function decrements J Appl Physiol, November 1, 1998; 85(5): 1863 - 1870. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
