ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published online before print April 16, 2008
Eur Respir J 2008, doi:10.1183/09031936.00093407
This Article
Right arrow Full Text (Rapid PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Ono, E.
Right arrow Articles by Akiyama, K.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ono, E.
Right arrow Articles by Akiyama, K.

ORIGINAL ARTICLE

Increased urinary leukotriene E4 concentration in patients with eosinophilic pneumonia

E. Ono 1*, M. Taniguchi 2, H. Mita 2, N. Higashi 2, Y. Fukutomi 2, H. Tanimoto 2, K. Sekiya 2, C. Oshikata 2, T. Tsuburai 2, N. Tsurikisawa 2, M. Otomo 2, Y. Maeda 2, O. Matsuno 3, E. Miyazaki 3, T. Kumamoto 3, K. Akiyama 2

1 Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa 228-8522, Japan; and Division of Third Dept of Internal Medicine, Oita University Faculty of Medicine, Yuhu, Oita 879-8893, Japan
2 Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa 228-8522, Japan
3 Division of Third Dept of Internal Medicine, Oita University Faculty of Medicine, Yuhu, Oita 879-8893, Japan

* To whom correspondence should be addressed. E-mail: e-ono{at}sagamihara-hosp.gr.jp.


  Abstract

Although eosinophils produce cysteinyl leukotrienes (CysLTs) in large quantity, information on relationship between CysLTs and eosinophilic pneumonia (EP) is lacking. We quantified inflammatory mediator concentrations in urine to clarify the relationship between CysLT concentrations and EP severity.

Leukotriene E4 (LTE4), eosinophil-derived neurotoxin (EDN), 9{alpha}, 11{beta}-prostaglandin F2 (9{alpha}, 11{beta}-PGF2), and LTB4 glucuronide (LTBG) concentrations were quantified in the urine of EP patients during acute exacerbation and clinical remission, asthmatic patients during acute exacerbation and under stable condition, and healthy control subjects.

The urinary LTE4 and EDN concentrations of EP patients during acute exacerbation were significantly higher than those of asthmatic patients and healthy subjects, and which immediately decreased during clinical remission. The urinary LTE4 concentration was associated with the urinary EDN concentration of EP patients during acute exacerbation. The urinary LTE4 concentration significantly correlated with the diffusing capacity of the lung for carbon monoxide (DLCO) in EP patients during acute exacerbation.

The increased urinary concentrations of LTE4 and EDN were associated with acute exacerbation in EP patients. The increased LTE4 concentration significantly correlated with DLCO, suggesting that the monitoring of LTE4 concentration may aid in the management of EP patients.

Keywords:  Biomarkers, bronchial asthma (asthma), diffusing capacity, eiocosanoids (prostaglandin and leukotrienes), eosinophilic pneumonia, leukotriene






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2008 by the European Respiratory Society.